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Open AccessAuthor Correction: Property space map** of Pseudomonas aeruginosa permeability to small molecules
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Article
Open AccessPotent and selective covalent inhibition of the papain-like protease from SARS-CoV-2
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The papain-like protease (PLpro) domain of Ns...
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Article
Open AccessProperty space map** of Pseudomonas aeruginosa permeability to small molecules
Two membrane cell envelopes act as selective permeability barriers in Gram-negative bacteria, protecting cells against antibiotics and other small molecules. Significant efforts are being directed toward under...
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Article
β-Barrel proteins tether the outer membrane in many Gram-negative bacteria
Gram-negative bacteria have a cell envelope that comprises an outer membrane (OM), a peptidoglycan (PG) layer and an inner membrane (IM)1. The OM and PG are load-bearing, selectively permeable structures that are...
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Article
Open AccessStructure determination of the HgcAB complex using metagenome sequence data: insights into microbial mercury methylation
Bacteria and archaea possessing the hgcAB gene pair methylate inorganic mercury (Hg) to form highly toxic methylmercury. HgcA consists of a corrinoid binding domain and a transmembrane domain, and HgcB is a diclu...
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Targeted isolation and cultivation of uncultivated bacteria by reverse genomics
Most microorganisms from all taxonomic levels are uncultured. Single-cell genomes and metagenomes continue to increase the known diversity of Bacteria and Archaea; however, while ’omics can be used to infer ph...
