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Open AccessHSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC), the most prevalent type of pancreatic cancer, is one of the deadliest forms of cancer with limited therapy options. Overexpression of the heat shock protein 70 (HSP70) ...
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Open AccessBRD4 promotes resection and homology-directed repair of DNA double-strand breaks
Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent a major source of genomic instability. Members of the bromodomain and extra-terminal (BET) protein family are characteriz...
