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  1. No Access

    Article

    Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei

    Topographical cues on cells can, through contact guidance, alter cellular plasticity and accelerate the regeneration of cultured tissue. Here we show how changes in the nuclear and cellular morphologies of hum...

    **nlong Wang, Vasundhara Agrawal, Cody L. Dunton… in Nature Biomedical Engineering (2023)

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    Article

    BOO induces fibrosis and EMT in urothelial cells which can be recapitulated in vitro through elevated storage and voiding pressure cycles

    To determine the unique contributions from elevated voiding and storage pressures in the development of fibrosis and the epithelial-to-mesenchymal transition (EMT) in urothelial cells, and how progressive BOO ...

    Cody L. Dunton, J. Todd Purves… in International Urology and Nephrology (2021)

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    Article

    Elevated hydrostatic pressure stimulates ATP release which mediates activation of the NLRP3 inflammasome via P2X4 in rat urothelial cells

    Partial bladder outlet obstruction (pBOO) is a prevalent urological condition commonly accompanied by increased intravesical pressure, inflammation, and fibrosis. Studies have demonstrated that pBOO results in...

    Cody L. Dunton, J. Todd Purves… in International Urology and Nephrology (2018)