26 Result(s)

Article

Alterations in PTEN and ESR1 promote clinical resistance to alpelisib plus aromatase inhibitors

Alpelisib is a selective inhibitor of phosphoinositide 3-kinase (PI3K)α, shown to improve outcomes for PIK3CA-mutant, hormone receptor–positive metastatic breast cancers when combined with antiestrogen therapy. T...

Pedram Razavi, Maura N. Dickler, Payal D. Shah, Weiyi Toy, David N. Brown… in Nature Cancer (2020)

Article

Local–regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial)

Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local–regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, howev...

Jennifer R. Bellon, Hao Guo, William T. Barry… in Breast Cancer Research and Treatment (2019)

Article

Identification of risk factors for toxicity in patients with hormone receptor-positive advanced breast cancer treated with bevacizumab plus letrozole: a CALGB 40503 (alliance) correlative study

In hormone receptor-positive advanced breast cancer, a progression-free survival benefit was reported with addition of bevacizumab to first-line letrozole. However, increased toxicity was observed. We hypothes...

Daneng Li, Linda M. McCall, Olwen M. Hahn… in Breast Cancer Research and Treatment (2018)

Article

The Impact of Obesity on Breast Cancer

The rates of obesity are increasing worldwide and this condition is now recognized as a leading preventable cause of cancer. Several diseases are directly related to obesity, including diabetes, hypertension, ...

Daniel F. Argolo, Clifford A. Hudis, Neil M. Iyengar in Current Oncology Reports (2018)

Article

Cardiac safety of non-anthracycline trastuzumab-based therapy for HER2-positive breast cancer

Trastuzumab improves overall survival for women with HER2-positive breast cancer but is associated with cardiotoxicity, especially when administered after anthracyclines. Use of non-anthracycline trastuzumab-b...

Anthony F. Yu, Roy B. Mukku, Shivani Verma… in Breast Cancer Research and Treatment (2017)

Article

Estimating the OncotypeDX score: validation of an inexpensive estimation tool

OncotypeDX, a multi-gene expression assay, has been incorporated into clinical practice as a prognostic and predictive tool. However, its use in resource-constrained international healthcare systems is limited...

Anne A. Eaton, Catherine E. Pesce, James O. Murphy… in Breast Cancer Research and Treatment (2017)

Article

Obesity and Cancer—Opportunities to Break the Link

Obesity is a major global health problem with a rising worldwide burden. In addition to its association with several diseases, obesity is associated with increased incidence and worse prognosis for many malign...

Daniel F. Argolo, Clifford A. Hudis, Neil M. Iyengar in Current Breast Cancer Reports (2016)

Article

Obesity and Cancer: Concepts and Challenges

The rates of overweight and obesity are increasing worldwide in both developed and develo** countries. Obesity is a major public health problem as it is associated with many diseases, including diabetes, hyp...

Daniel F. Argolo, Neil M. Iyengar, Clifford A. Hudis in Indian Journal of Surgical Oncology (2015)

Article

Appearance of untreated bone metastases from breast cancer on FDG PET/CT: importance of histologic subtype

To determine if the histology of a breast malignancy influences the appearance of untreated osseous metastases on FDG PET/CT.

Brittany Z. Dashevsky, Debra A. Goldman… in European Journal of Nuclear Medicine and M… (2015)

Article

Trastuzumab interruption and treatment-induced cardiotoxicity in early HER2-positive breast cancer

Trastuzumab improves outcomes among patients with HER2-positive breast cancer but is associated with a risk of treatment-induced cardiotoxicity (TIC). It is unclear how frequently TIC leads to trastuzumab inte...

Anthony F. Yu, Nandini U. Yadav, Betty Y. Lung… in Breast Cancer Research and Treatment (2015)

Article

Omega-3 Fatty Acids for Prevention of Breast Cancer: an Update and the State of the Science

The quantity and makeup of dietary fat intake are known to affect human health. A variety of purported health benefits, including cancer prevention, have focused increased attention on use of omega-3 (ω-3) pol...

Neil M. Iyengar, Clifford A. Hudis, Ayca Gucalp in Current Breast Cancer Reports (2013)

Article

Cognitive function in older women with breast cancer treated with standard chemotherapy and capecitabine on Cancer and Leukemia Group B 49907

Cognitive changes in older women receiving chemotherapy are poorly understood. We examined self-reported cognitive function for older women who received adjuvant chemotherapy on Cancer and Leukemia Group B (CA...

Rachel A. Freedman, Brandelyn Pitcher… in Breast Cancer Research and Treatment (2013)

Article

The role of targeted therapy and biomarkers in breast cancer treatment

Breast cancer is the most prevalent life-threatening cancer in women and the second leading cause of cancer associated deaths. Consequently, optimizing breast cancer therapy to increase cure rates in early sta...

Alison T. Stopeck, Ursa Brown-Glaberman… in Clinical & Experimental Metastasis (2012)

Article

Phase II trial of a novel capecitabine dosing schedule in combination with lapatinib for the treatment of patients with HER2-positive metastatic breast cancer

Our group applied mathematical modeling to capecitabine dosing and predicted 7 days of treatment followed by 7 days of rest (7–7) would improve efficacy and minimize toxicity. The conventional schedule of cape...

Devika Gajria, Joseph Gonzalez, Kimberly Feigin… in Breast Cancer Research and Treatment (2012)

Article

Anthracyclines and trastuzumab; getting to the heart of the matter: when getting to the heart is the matter

Patrick G. Morris, Clifford A. Hudis in Breast Cancer Research and Treatment (2011)