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Article
Open AccessCyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understo...
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Protocol
In Vivo and In Vitro Assay to Address Dendritic Cell Antigen Cross-Presenting Capacity
Antigen cross-presentation by dendritic cells is an important pathway to prime CD8+ T cells in infections, cancer, and other immune-mediated pathologies. Particularly in cancer, cross-presentation of tumor-associ...
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Article
Open AccessThe RNase MCPIP3 promotes skin inflammation by orchestrating myeloid cytokine response
CCCH zinc finger proteins resolve immune responses by degrading the mRNAs of inflammatory cytokines such as tumor necrosis factor (TNF) and interleukin (IL)-6. Here we report that one such family member, monoc...
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Article
The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets
Id proteins negatively regulate the binding of E-protein transcription factors to DNA. Goldrath et al. show that Id2 and Id3 are important in the generation of memory in distinct functional populations of CD8+ ce...
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Article
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Cytokine-producing innate lymphoid cells are found at mucosal surfaces. Artis and Wherry and their colleagues show that innate 'nuocyte-like' cells accumulate in virus-infected lungs and contribute to the repa...
