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  1. No Access

    Article

    Structural basis of the complete poxvirus transcription initiation process

    Poxviruses express their genes in the cytoplasm of infected cells using a virus-encoded multi-subunit polymerase (vRNAP) and unique transcription factors. We present cryo-EM structures that uncover the complet...

    Clemens Grimm, Julia Bartuli, Bettina Boettcher… in Nature Structural & Molecular Biology (2021)

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    Article

    ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space

    ProteoPlex optimizes buffer conditions for the isolation and purification of macromolecular complexes. The concurrent complex stabilization is beneficial for structure determination using X-ray crystallography...

    Ashwin Chari, David Haselbach, Jan-Martin Kirves, Juergen Ohmer… in Nature Methods (2015)