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Article
Open AccessA ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely controls developmental and tumor angiogenesis. In the absence of Netrin-1, UNC5B ind...
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Article
Alternative splicing in Alzheimer’s disease
Alzheimer’s disease (AD) is the most frequent neurodegenerative disorder in the elderly, occurring in approximately 20% of people older than 80. The molecular causes of AD are still poorly understood. However,...
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Article
Open AccessAlternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis
Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue hom...
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Article
Open AccessDiversification of the muscle proteome through alternative splicing
Skeletal muscles express a highly specialized proteome that allows the metabolism of energy sources to mediate myofiber contraction. This muscle-specific proteome is partially derived through the muscle-specif...
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Article
Open AccessEMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity...
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Article
Open AccessThe alternative splicing factor Nova2 regulates vascular development and lumen formation
Vascular lumen formation is a fundamental step during angiogenesis; yet, the molecular mechanisms underlying this process are poorly understood. Recent studies have shown that neural and vascular systems share...
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Chapter
Alternative Splicing of Tumor Suppressors and Oncogenes
Alternative splicing is a fundamental mechanism to modulate gene expression programs in response to different growth and environmental stimuli. There is now ample evidence that alternative splicing errors, cau...
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Article
Making alternative splicing decisions during epithelial-to-mesenchymal transition (EMT)
Alternative splicing generates multiple mRNAs from a single transcript and is a major contributor to proteomic diversity and to the control of gene expression in complex organisms. Not surprisingly, this post-...
