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  1. Article

    Open Access

    The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

    Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in the immunoglobulin (Ig) switch regions. Here we show...

    Conglei Li, Thergiory Irrazabal, Clare C. So, Maribel Berru… in Nature Communications (2018)

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  2. Article

    Open Access

    Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching

    Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wi...

    Michael X. Le, Dania Haddad, Alexanda K. Ling, Conglei Li… in Scientific Reports (2016)

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