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Article
Open AccessThe H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining
Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in the immunoglobulin (Ig) switch regions. Here we show...
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Article
Open AccessKin17 facilitates multiple double-strand break repair pathways that govern B cell class switching
Class switch recombination (CSR) in B cells requires the timely repair of DNA double-stranded breaks (DSBs) that result from lesions produced by activation-induced cytidine deaminase (AID). Through a genome-wi...