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  1. Article

    Open Access

    Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial

    Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL...

    Claire Schwab, Ruth E. Cranston, Sarra L. Ryan, Ellie Butler, Emily Winterman… in Leukemia (2023)

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  2. Article

    Open Access

    Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study

    Chromosomal abnormalities are established prognostic markers in adult ALL. We assessed the prognostic impact of established chromosomal abnormalities and key copy number alterations (CNA) among 652 patients wi...

    Anthony V. Moorman, Emilio Barretta, Ellie R. Butler, Eleanor J. Ward… in Leukemia (2022)

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  3. Article

    Open Access

    Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

    Judith M. Boer, Maria Grazia Valsecchi, Femke M. Hormann, Željko Antić… in Leukemia (2021)

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  4. No Access

    Chapter

    Cytogenetics and Molecular Genetics

    In childhood acute lymphoblastic leukaemia (ALL), chromosomal abnormalities are important diagnostic and prognostic biomarkers, which are used in risk stratification. For example, t(12;21)/ETV6-RUNX1 and high hyp...

    Christine J. Harrison, Anthony V. Moorman… in Childhood Acute Lymphoblastic Leukemia (2017)