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Article
Open AccessIntegrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial
Incorporating genetics into risk-stratification for treatment of childhood B-progenitor acute lymphoblastic leukaemia (B-ALL) has contributed significantly to improved survival. In about 30% B-ALL (B-other-ALL...
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Article
Open AccessPrognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study
Chromosomal abnormalities are established prognostic markers in adult ALL. We assessed the prognostic impact of established chromosomal abnormalities and key copy number alterations (CNA) among 652 patients wi...
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Article
Open AccessFavorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study
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Chapter
Cytogenetics and Molecular Genetics
In childhood acute lymphoblastic leukaemia (ALL), chromosomal abnormalities are important diagnostic and prognostic biomarkers, which are used in risk stratification. For example, t(12;21)/ETV6-RUNX1 and high hyp...
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Article
Open AccessZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Early T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding tran...
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Article
Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia
A rare constitutional translocation between chromosomes 15 and 21 predisposes to catastrophic chromosomal damage followed by amplification of megabase regions, causing a specific subtype of acute lymphoblastic...
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Protocol
Acute Lymphoblastic Leukaemia
Cytogenetics plays an important role in the diagnosis of acute lymphoblastic leukaemia (ALL), particularly in relation to the association of specific chromosomal abnormalities with outcome. The karyotype at di...
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Article
PHF6 mutations in T-cell acute lymphoblastic leukemia
Adolfo Ferrando and colleagues identify frequent inactivating mutations and deletions in the X chromosome gene PHF6 in T-cell acute lymphoblastic leukemia. PHF6 mutations are found almost exclusively in males and...
