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  1. No Access

    Protocol

    Automated Patch Clamp Recordings of GPCR-Gated Ion Channels: Targeting the MC4-R/Kir7.1 Potassium Channel Complex

    Automated patch clamp recording is a valuable technique in drug discovery and the study of ion channels. It allows for the precise measurement and manipulation of channel currents, providing insights into thei...

    Ciria C. Hernandez, Luis E. Gimenez, Roger D. Cone in Potassium Channels (2024)

  2. No Access

    Article

    Targeting the central melanocortin system for the treatment of metabolic disorders

    A large body of preclinical and clinical data shows that the central melanocortin system is a promising therapeutic target for treating various metabolic disorders such as obesity and cachexia, as well as anor...

    Patrick Sweeney, Luis E. Gimenez, Ciria C. Hernandez… in Nature Reviews Endocrinology (2023)

  3. Article

    Open Access

    GABA A Receptor Coupling Junction and Pore GABRB3 Mutations are Linked to Early-Onset Epileptic Encephalopathy

    GABAA receptors are brain inhibitory chloride ion channels. Here we show functional analyses and structural simulations for three de novo missense mutations in the GABAA receptor β3 subunit gene (GABRB3) identifi...

    Ciria C. Hernandez, Yujia Zhang, Ningning Hu, Dingding Shen… in Scientific Reports (2017)

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  4. No Access

    Article

    Co-expression of γ2 Subunits Hinders Processing of N-Linked Glycans Attached to the N104 Glycosylation Sites of GABAA Receptor β2 Subunits

    GABAA receptors, the major mediators of fast inhibitory neuronal transmission, are heteropentameric glycoproteins assembled from a panel of subunits, usually including α and β subunits with or without a γ2 subuni...

    Wen-yi Lo, Andre H. Lagrange, Ciria C. Hernandez… in Neurochemical Research (2014)