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Article
Open AccessSocioeconomic disadvantage and impact on visual outcomes in patients with viral retinitis and retinal detachment
While socioeconomic disparities impact clinical care and patient outcomes, their impact on the anatomic and visual outcomes of retinal detachment in patients with viral retinitis is unstudied. This case series in...
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Article
Open AccessTyrosine O-sulfation proteoforms affect HIV-1 monoclonal antibody potency
CAP256V2LS, a broadly neutralizing monoclonal antibody (bNAb), is being pursued as a promising drug for HIV-1 prevention. The total level of tyrosine-O-sulfation, a post-translational modification, was known to p...
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Chapter
Anti-Vascular Endothelial Growth Factor for Neovascular Glaucoma
Neovascular glaucoma (NVG) is an aggressive form of secondary glaucoma that occurs in eyes with underlying ischemic retinal vascular disease. Vascular endothelial growth factor (VEGF) plays a critical role in ...
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Article
Time to disease recurrence in noninfectious uveitis following long-acting injectable fluocinolone acetonide implant
To determine the time to disease recurrence with long-acting injectable fluocinolone acetonide implant (FAi) for noninfectious intermediate, posterior, and panuveitis.
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Article
Characterization of AEBSF-antibody modifications for a protease inhibitor supplementation strategy
Application of a protease inhibitor, 4-(2-aminoethyl) benzenesulfonyl fluoride (AEBSF), during the cell culture process was demonstrated to effectively reduce proteolytic activity at a specific amino acid site...
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Article
Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis
Hyperinsulinemia and insulin resistance are hallmark features of nonalcoholic fatty liver disease and steatohepatitis (NASH). It remains unclear whether and how insulin contributes to the development of fibros...
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Article
Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway
The expression of kidney injury molecule-1 (KIM-1), a very promising sensitive and specific urinary biomarker for acute renal injury, is markedly upregulated in injured and regenerating renal proximal tubular ...
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Article
A Treat-to-Target Concept to Guide the Medical Management of Hepatorenal Syndrome
The principle of treating-to-target has been successfully applied to many diseases with significant improvement in patient care and as a useful guidance for healthcare providers. Appreciation of the central ro...
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Chapter
Corneal Epithelial Nuclear Ferritin and Its Transporter Ferritoid Afford Unique Protection to DNA from UV Light and Reactive Oxygen Species
Ultraviolet (UV) light constitutes a major environmental hazard for all exposed tissues of the body. UV light can damage a variety of macromolecules—including alterations to DNA that are potentially carcinogen...
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Article
Targeting an Early and Substantial Increase in Mean Arterial Pressure Is Critical in the Management of Type 1 Hepatorenal Syndrome: A Combined Retrospective and Pilot Study
Appreciation of the central role for arterial vasodilatation in the pathogenesis of hepatorenal syndrome (HRS) has led to routine use of vasoconstrictors in combination with albumin as a medical therapy for HR...
