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Article
Open AccessPPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
Here, in Ppara−/− mice, we found that an increased DNL stimulated the cartilage degradation and identified ACOT12 as a key regulatory factor. Suppressed level of ACOT12 was observed in cartilages of OA patient an...
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Article
Open AccessQuantitative assessment of neural elements in a rat model using nerve growth factor after remnant-preserving anterior cruciate ligament reconstruction: a histological and immunofluorescence pilot study
Immunofluorescence analyses of anterior cruciate ligament (ACL) allografts following remnant-preserving ACL reconstruction using Achilles tendon allografts have provided evidence for the presence of neural ele...
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Article
Correction to: Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function
In Fig. 1C, the wrong si-control image was used by mistake.
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Article
Open AccessCorrection to: MicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin
Following publication of the original article [1], the authors reported that Figs. 3 and 6 are incorrect.
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Article
The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis
Osteoarthritis—the most common form of age-related degenerative whole-joint disease1—is primarily characterized by cartilage destruction, as well as by synovial inflammation, osteophyte formation and subchondral ...
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Article
Open AccessRNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family
Osteoarthritis (OA) is a whole-joint disease characterized by cartilage destruction and other whole-joint pathological changes. There is currently no effective disease-modifying therapy. Here we investigate th...
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Article
Open AccessDysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
Osteoarthritis (OA) is the most common degenerative joint disease; however, its etiopathogenesis is not completely understood. Here we show a role for NUDT7 in OA pathogenesis. Knockdown of NUDT7 in normal human ...
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Article
Open AccessA case of bilateral revision total knee arthroplasty using distal femoral allograft–prosthesis composite and femoral head allografting at the tibial site with a varus-valgus constrained prosthesis: ten-year follow up
We report the successful use of allograft–prosthesis composite (APC) and structural femoral head allografting in the bilateral reconstruction of large femoral and tibial uncontained defects during revision tot...
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Article
Open AccessEstrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
The estrogen-related receptor (ERR) family of orphan nuclear receptor is composed of ERRα, ERRβ, and ERRγ, which are known to regulate various isoform-specific functions under normal and pathophysiological con...
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Article
Open AccessClinical and radiological results of cruciate-retaining total knee arthroplasty with the NexGen®-CR system: comparison of patellar resurfacing versus retention with more than 14 years of follow-up
The purpose of this study is to analyze clinical and radiological outcomes of patients (with a minimum of 14 years of follow-up) who underwent cruciate-retaining (CR) total knee arthroplasty (TKA) using a NexG...
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Article
Open AccessImmunohistochemical and immunocytochemical study of mechanoreceptors in anterior cruciate ligament reconstruction with the remnant-preserving technique using Achilles tendon allografts
Attempts have been made to validate the significance of remnant preservation with anterior cruciate ligament (ACL) reconstruction using immunohistochemical and immunocytochemical techniques. The purpose of thi...
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Article
Fis1 depletion in osteoarthritis impairs chondrocyte survival and peroxisomal and lysosomal function
Cumulative evidence suggests the importance of organelle homeostasis in regulating metabolic functions in response to various cellular stresses. Particularly, the dynamism and health of the mitochondria-peroxi...
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Article
Open AccessMicroRNA-9 regulates survival of chondroblasts and cartilage integrity by targeting protogenin
Studies have shown the roles of miR-9 and its validated target, protogenin (PRTG) in the differentiation of chondroblasts to chondrocyte and in the pathogenesis of osteoarthritis (OA). We hypothesized that miR...
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Article
Open AccessMicroRNA-488 regulates zinc transporter SLC39A8/ZIP8 during pathogenesis of osteoarthritis
Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due to lack of understanding in OA pathology. To better understand ...
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Article
Arthroscopic treatment of lateral epicondylitis: comparison of the outcome of ECRB release with and without decortication
The purpose of this study was to compare the early clinical results of arthroscopic extensor carpi radialis brevis (ECRB) release with and without bone decortication in the treatment of lateral epicondylitis.
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Article
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
In two studies from teams led by Hiroshi Kawaguchi and Jang-Soo Chun, a role for HIF-2α in osteoarthritis has been uncovered. Along with identifying the molecular mechanism, the teams found that HIF-2α express...
