6 Result(s)
within
Chunyan Ji
Biomedicine, general
-
Article
Open AccessEIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway
Aberrant expression of circRNAs has been proven to play a crucial role in the progression of acute myeloid leukemia (AML); however, its regulatory mechanism remains unclear. Herein, we identified a novel circR...
-
Article
Open AccessLkb1 aggravates diffuse large B-cell lymphoma by promoting the function of Treg cells and immune escape
Regulatory T cells (Tregs) induce immune responses and may contribute to immune escape in tumors. Accumulation of Tregs in tumors represents a critical barrier to anti-tumor immunity and immunotherapy. However...
-
Article
Open AccessRole of CDH23 as a prognostic biomarker and its relationship with immune infiltration in acute myeloid leukemia
Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on the prog...
-
Article
Open AccessEarly BCR-ABL1 decline in imatinib-treated patients with chronic myeloid leukemia: results from a multicenter study of the Chinese CML alliance
An early molecular response is spectacularly predictive of outcome in chronic myeloid leukemia (CML) and early response landmarks may identify the high-risk patients likely to be benefit from an early therapy ...
-
Article
Open AccessWnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation
We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In thi...
-
Article
Open AccessThe emerging roles of Notch signaling in leukemia and stem cells
The Notch signaling pathway plays a critical role in maintaining the balance between cell proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that regulates normal develop...
