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Open AccessTargeting neddylation and sumoylation in chemoresistant triple negative breast cancer
Triple negative breast cancer (TNBC) accounts for 15–20% of breast cancer cases in the United States. Systemic neoadjuvant chemotherapy (NACT), with or without immunotherapy, is the current standard of care fo...
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Article
Open AccessPredictors of success in establishing orthotopic patient-derived xenograft models of triple negative breast cancer
Patient-derived xenograft (PDX) models of breast cancer are an effective discovery platform and tool for preclinical pharmacologic testing and biomarker identification. We established orthotopic PDX models of ...
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Article
Open AccessTargeted RNAseq assay incorporating unique molecular identifiers for improved quantification of gene expression signatures and transcribed mutation fraction in fixed tumor samples
Our objective was to assess whether modifications to a customized targeted RNA sequencing (RNAseq) assay to include unique molecular identifiers (UMIs) that collapse read counts to their source mRNA counts wou...
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Comments on the development of blockchain technology from the perspective of patent analysis
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Open AccessThe impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues
Utilization of RNA sequencing methods to measure gene expression from archival formalin-fixed paraffin-embedded (FFPE) tumor samples in translational research and clinical trials requires reliable interpretati...
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Article
Open AccessSETER/PR: a robust 18-gene predictor for sensitivity to endocrine therapy for metastatic breast cancer
There is a clinical need to predict sensitivity of metastatic hormone receptor-positive and HER2-negative (HR+/HER2−) breast cancer to endocrine therapy, and targeted RNA sequencing (RNAseq) offers diagnostic ...
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Article
A Bayesian approach for sleep and wake classification based on dynamic time war** method
Sleep plays a significant role in human’ smental and physical health. Recently, the associations between lack of sleep and weight gain, development of cancer and many other health problems have been recognized...
