8 Result(s)

Article

An inorganic mineral-based protocell with prebiotic radiation fitness

Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of life. However, little is known about protocell’s survival and fitness under prebiotic radiations. Here we present...

Shang Dai, Zhenming **e, Binqiang Wang, Rui Ye, **nwen Ou… in Nature Communications (2023)

Article

An individualized Bayesian method for estimating genomic variants of hypertension

Genomic variants of the disease are often discovered nowadays through population-based genome-wide association studies (GWAS). Identifying genomic variations potentially underlying a phenotype, such as hyperte...

Md Asad Rahman, Chunhui Cai, Na Bo, Dennis M. McNamara, Ying Ding… in BMC Genomics (2023)

Article

Glioma stem cells and neural stem cells respond differently to BMP4 signaling

Malignant glioma is a highly heterogeneous and invasive primary brain tumor characterized by high recurrence rates, resistance to combined therapy, and dismal prognosis. Glioma stem cells (GSCs) are likely res...

**n-**n Han, Chunhui Cai, Li-Ming Yu, Min Wang, Wenhan Yang, Dai-Yu Hu… in Cell Regeneration (2022)

Article

Interferon-beta inhibits human glioma stem cell growth by modulating immune response and cell cycle related signaling pathways

Malignant Glioma is characterized by strong self-renewal potential and immature differentiation potential. The main reason is that malignant glioma holds key cluster cells, glioma stem cells (GSCs). GSCs contr...

**n-**n Han, Shengkai **, Li-Ming Yu, Min Wang, **n-Yu Hu, Dai-Yu Hu… in Cell Regeneration (2022)

Article

c-Myc regulates neural stem cell quiescence and activation by coordinating the cell cycle and mitochondrial remodeling

Chunhui Cai, **nyu Hu, Peibin Dai… in Signal Transduction and Targeted Therapy (2021)

Article

Tumour-specific Causal Inference Discovers Distinct Disease Mechanisms Underlying Cancer Subtypes

Cancer is a disease mainly caused by somatic genome alterations (SGAs) that perturb cellular signalling systems. Furthermore, the combination of pathway aberrations in a tumour defines its disease mechanism, a...

Yifan Xue, Gregory Cooper, Chunhui Cai, Songjian Lu, Baoli Hu… in Scientific Reports (2019)

Article

Unsupervised deep learning reveals prognostically relevant subtypes of glioblastoma

One approach to improving the personalized treatment of cancer is to understand the cellular signaling transduction pathways that cause cancer at the level of the individual patient. In this study, we used uns...

Jonathan D. Young, Chunhui Cai, **nghua Lu in BMC Bioinformatics (2017)

Article

Learning a hierarchical representation of the yeast transcriptomic machinery using an autoencoder model

A living cell has a complex, hierarchically organized signaling system that encodes and assimilates diverse environmental and intracellular signals, and it further transmits signals that control cellular respo...

Lujia Chen, Chunhui Cai, Vicky Chen, **nghua Lu in BMC Bioinformatics (2016)