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  1. Article

    Open Access

    High vs. low radiotherapy dose in locally advanced esophageal squamous cell carcinoma patients treated with neoadjuvant concurrent chemoradiotherapy: an endemic area population-based study

    The optimal radiotherapy dose for locally advanced esophageal squamous cell carcinoma in endemic areas treated with neoadjuvant concurrent chemoradiotherapy is unclear.

    Chia-Chin Li, Chih-Yi Chen, Ying-Hsiang Chou, Chih-Jen Huang in Discover Oncology (2022)

  2. Article

    Open Access

    Consolidative chemotherapy after definitive concurrent chemoradiotherapy for esophageal squamous cell carcinoma patients: a population based cohort study

    The role of consolidative chemotherapy (CCT) for locally advanced esophageal squamous cell carcinoma (LA-ESCC) patients treated with definitive concurrent chemoradiotherapy (dCCRT) is unclear. We aimed to comp...

    Chen-Yuan Lin, Ming-Yu Lien, Chi-Ching Chen, Hsin-Yuan Fang in BMC Gastroenterology (2022)

  3. Article

    Open Access

    Chemotherapy alone versus definitive concurrent chemoradiotherapy for cT4b esophageal squamous cell carcinoma: a population-based study

    The role of radiotherapy for cT4bNanyM0 esophageal squamous cell carcinoma (ESqCC) is relatively unclear, with both chemotherapy (C/T) alone and definitive concurrent chemoradiotherapy (dCCRT) being treatment ...

    Chia-Chin Li, Chih-Yi Chen, Ying-Hsiang Chou, Chih-Jen Huang in BMC Gastroenterology (2021)

  4. Article

    The importance of out-of-pocket cost information in the era of financial toxicity of cancer care

    Fy-Uan Chang, Chun-Ru Chien in Supportive Care in Cancer (2021)

  5. Article

    Open Access

    Impact of the interval between neoadjuvant concurrent chemoradiotherapy and esophagectomy in the modern era: a population-based propensity-score-matched retrospective cohort study in Asia

    Neoadjuvant concurrent chemoradiotherapy (nCCRT) is one of the standard-of-care options for locally advanced esophageal squamous cell carcinoma (LA-ESqCC). The optimal interval between nCCRT and esophagectomy ...

    Yao-Hung Kuo, Yu-Wen Chien, Pin-Ru Chen in World Journal of Surgical Oncology (2019)

  6. No Access

    Article

    Rising Economic Burden of Renal Cell Carcinoma among Elderly Patients in the USA: Part II—An Updated Analysis of SEER-Medicare Data

    The influx of new oncologic technologies has changed the treatment landscape of renal cell carcincoma (RCC) in the last decade. This study updated a previously published paper on the economic burden of RCC in ...

    Ya-Chen Tina Shih, Ying Xu, Chun-Ru Chien, Bumyang Kim, Yu Shen in PharmacoEconomics (2019)

  7. Article

    A Prognostic Score for Brain Metastases of Non-small-cell Lung Cancer in the Era of Precision Medicine

    Hua-Shai Hsu, Sung-Lin Hu, Chun-Ru Chien in Lung (2019)

  8. No Access

    Article

    Economic Burden of Renal Cell Carcinoma—Part I: An Updated Review

    The economic burden of renal cell carcinoma (RCC) had been reported to be significant in a previous review published in 2011.

    Chun-Ru Chien, Daniel M. Geynisman, Bumyang Kim, Ying Xu in PharmacoEconomics (2019)

  9. Article

    Open Access

    Neoadjuvant vs definitive concurrent chemoradiotherapy in locally advanced esophageal squamous cell carcinoma patients

    The optimal treatment for locally advanced esophageal squamous cell carcinoma remains unclear. We compared the clinical outcomes of neoadjuvant concurrent chemoradiotherapy (CCRT) followed by esophagectomy [th...

    Chih-Yi Chen, Chia-Chin Li, Chun-Ru Chien in World Journal of Surgical Oncology (2018)

  10. Article

    Open Access

    A topology-based method to mitigate the dosimetric uncertainty caused by the positional variation of the boost volume in breast conservative radiotherapy

    To improve local control rate in patients with breast cancer receiving adjuvant radiotherapy after breast conservative surgery, additional boost dose to the tumor bed could be delivered simultaneously via the ...

    Peng-Yi Lee, Chih-Yuan Lin, Shang-Wen Chen, Chun-Ru Chien in Radiation Oncology (2017)

  11. No Access

    Article

    Questionable role of adjuvant chemotherapy in rectal cancer patients who had reached pathological complete response after neoadjuvant concurrent chemoradiotherapy: no matter in the East or in the West

    William Tzu-Liang Chen, Tao-Wei Ke in Journal of Cancer Research and Clinical On… (2014)

  12. No Access

    Article

    Cost-Effectiveness Analyses of Targeted Oral Anti-Cancer Drugs: A Systematic Review

    Over the last 15 years, a paradigm shift in oncology has led to the approval of dozens of targeted oral anti-cancer medications (OAMs), which have become the standard of care for certain cancers. While more co...

    Fabrice Smieliauskas, Chun-Ru Chien, Chan Shen, Daniel M. Geynisman in PharmacoEconomics (2014)

  13. No Access

    Article

    Use of FDG-PET or PET/CT to detect recurrent colorectal cancer in patients with elevated CEA: a systematic review and meta-analysis

    The purpose of the present study was to conduct a systematic review and meta-analysis of the published literature to assess the diagnostic performance of FDG-PET or PET/CT in the detection of recurrent colorec...

    Yu-Yu Lu, **-Hua Chen, Chun-Ru Chien in International Journal of Colorectal Disease (2013)

  14. No Access

    Article

    Concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications: a population-based cohort study

    We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors.

    Hsin-Hui Tsai, Hsiang-Wen Lin, Chun-Ru Chien in European Journal of Clinical Pharmacology (2013)

  15. Article

    Open Access

    IMRT treatment plans and functional planning with functional lung imaging from 4D-CT for thoracic cancer patients

    Currently, the inhomogeneity of the pulmonary function is not considered when treatment plans are generated in thoracic cancer radiotherapy. This study evaluates the dose of treatment plans on highly-functiona...

    Tzung-Chi Huang, Chien-Yi Hsiao, Chun-Ru Chien, Ji-An Liang in Radiation Oncology (2013)

  16. No Access

    Article

    Economic Burden of Renal Cell Carcinoma

    The economic burden of renal cell carcinoma (RCC) came into sharp focus when the UK National Institute for Health and Clinical Excellence (NICE) denied coverage (later reversed) of sunitinib for metastatic RCC...

    Dr Ya-Chen T. Shih, Chun-Ru Chien, Ying Xu, I-Wen Pan, Grace L. Smith in PharmacoEconomics (2011)

  17. No Access

    Article

    Economic Burden of Renal Cell Carcinoma in the US

    Introduction: The economic burden of renal cell carcinoma (RCC) came into sharp focus when the UK’s National Institute for Health and Clinical Excellence denied coverage (later reversed) of sunit...

    Dr Ya-Chen T. Shih, Chun-Ru Chien, Ying Xu, I-Wen Pan, Grace L. Smith in PharmacoEconomics (2011)

  18. Article

    Open Access

    18F-FDG PET/CT-based gross tumor volume definition for radiotherapy in head and neck Cancer: a correlation study between suitable uptake value threshold and tumor parameters

    To define a suitable threshold setting for gross tumor volume (GTV) when using 18Fluoro-deoxyglucose positron emission tomography and computed tomogram (PET/CT) for radiotherapy planning in head and neck cancer (...

    Chia-Hung Kao, Te-Chun Hsieh, Chun-Yen Yu, Kuo-Yang Yen in Radiation Oncology (2010)

  19. No Access

    Article

    Excellent survival of pediatric dermatofibrosarcoma protuberans in Taiwanese

    The purpose of this study was to explore the clinical outcome of pediatric dermatofibrosarcoma protuberans (DFSP) in Taiwan. Patients with DFSP diagnosed before 18 years and treated in our institute from 1977 ...

    Chun-Ru Chien, Yih-Leong Chang, Dong-Tsamnn Lin in Pediatric Surgery International (2007)