38 Result(s)

Article

The roles of neural stem cells in myelin regeneration and repair therapy after spinal cord injury

Spinal cord injury (SCI) is a complex tissue injury that results in a wide range of physical deficits, including permanent or progressive disabilities of sensory, motor and autonomic functions. To date, limita...

Chun Li, Yu** Luo, Siguang Li in Stem Cell Research & Therapy (2024)

Article

Zinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis

The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, ...

Yu Yan, Wenyi Huang, **aoting Lu, **anxian Chen, Yingyi Shan… in Cell Biology and Toxicology (2024)

Article

Retraction Note: FoxM1-mediated RFC5 expression promotes temozolomide resistance

Wan-xin Peng, **u Han, Chun-li Zhang, Lu Ge, Feng-yi Du… in Cell Biology and Toxicology (2024)

Article

Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Prostatitis is a highly prevalent condition that seriously affects men’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep a...

Jia Chen, Wenming Ma, Shaoyu Yue, Dongsheng Li… in Cell Communication and Signaling (2024)

Article

Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease

Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived ...

Meng-Lu Liu, Shuaipeng Ma, Wenjiao Tai, **aoling Zhong, Haoqi Ni… in Cell Death & Disease (2024)

Article

B cell-derived anti-beta 2 glycoprotein I antibody mediates hyperhomocysteinemia-aggravated hypertensive glomerular lesions by triggering ferroptosis

Hyperhomocysteinemia (HHcy) is a risk factor for chronic kidney diseases (CKDs) that affects about 85% CKD patients. HHcy stimulates B cells to secrete pathological antibodies, although it is unknown whether t...

**ng Du, **aolong Ma, Ying Tan, Fangyu Shao… in Signal Transduction and Targeted Therapy (2023)

Article

BMX, a specific HDAC8 inhibitor, with TMZ for advanced CRC therapy: a novel synergic effect to elicit p53-, β-catenin- and MGMT-dependent apoptotic cell death

Despite advances in treatment, patients with refractory colorectal cancer (CRC) still have poor long-term survival, so there is a need for more effective therapeutic options.

Huey-Jiun Ko, Shean-Jaw Chiou, Cheng-Yu Tsai… in Cell Communication and Signaling (2022)

Article

Natural antisense RNA Foxk1-AS promotes myogenic differentiation by inhibiting Foxk1 activity

Natural antisense RNAs are RNA molecules that are transcribed from the opposite strand of either protein-coding or non-protein coding genes and have the ability to regulate the expression of their sense gene o...

Chun Li, Hao Shen, Meng Liu, Siguang Li, Yu** Luo in Cell Communication and Signaling (2022)

Article

ZBTB7A, a miR-144-3p targeted gene, accelerates bladder cancer progression via downregulating HIC1 expression

Zinc finger and BTB domain-containing 7A (ZBTB7A) is a member of the POK family of transcription factors that plays an oncogenic or tumor-suppressive role in different cancers depending on the type and genetic...

Junqiang Liu, Zhiyuan Chou, Chun Li, Kai Huang, Xuejian Wang… in Cancer Cell International (2022)

Article

Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial

Rheumatoid arthritis (RA) is an aggressive autoimmune arthritis, and current therapies remain unsatisfactory due to low remission rate and substantially adverse effects. Low-dose interleukin-2 (Ld-IL2) is pote...

**aoying Zhang, Miao Miao, Ruijun Zhang, Xu Liu… in Signal Transduction and Targeted Therapy (2022)

Article

Induction of apoptosis and autosis in cardiomyocytes by the combination of homocysteine and copper via NOX-mediated p62 expression

High levels of homocysteine (Hcy) associated with cardiovascular events are accompanied by increased copper (Cu) concentrations in the blood. Hcy has been shown to promote endothelial dysfunction, whereas the ...

Ran Yin, Huan Wang, Chun Li, Lulu Wang, Songqing Lai, **anhe Yang… in Cell Death Discovery (2022)

Article

ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway

Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the urgent need to seek novel therapeutic targets. Arylsu...

Yun Lin, Chun Li, Wei **ong, Li** Fan, Hongchao Pan, Yaochen Li in Cell Death & Disease (2021)

Article

Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial

It’s a challenge for detecting the therapeutic targets of a polypharmacological drug from variations in the responsed networks in the differentiated populations with complex diseases, as stable coronary heart ...

Jun Liu, Dan-Dan Li, Wei Dong, Yu-Qi Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Correction to: Reduced nNOS activity is responsible for impaired fatty acid–dependent mitochondrial oxygen consumption in atrial myocardium from hypertensive rat

The above article was published online with an error in affiliations.

Yu Na Wu, Chun Li **, Ji Hyun Jang… in Pflügers Archiv - European Journal of Phys… (2020)

Article

High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction

Obesity has been recognized as a major risk factor for chronic kidney disease, but the underlying mechanism remains elusive. Here, we investigated the mechanism whereby long-term high-fat diet (HFD) feeding in...

Yue Sun, **n Ge, Xue Li, **rong He, **nzhi Wei, Jie Du, Jian Sun… in Cell Death & Disease (2020)

Article

Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 °C

Yuanwei Cao, Wen Sun, **feng Wang, Gang Sheng, Guanghai **ang… in Cell Discovery (2019)