70 Result(s)
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Open AccessZinc oxide nanoparticles induces cell death and consequently leading to incomplete neural tube closure through oxidative stress during embryogenesis
The implementation of Zinc oxide nanoparticles (ZnO NPs) raises concerns regarding their potential toxic effects on human health. Although more and more researches have confirmed the toxic effects of ZnO NPs, ...
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Recent advances in lycopene and germacrene a biosynthesis and their role as antineoplastic drugs
Sesquiterpenes and tetraterpenes are classes of plant-derived natural products with antineoplastic effects. While plant extraction of the sesquiterpene, germacrene A, and the tetraterpene, lycopene suffers sup...
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Open AccessRetraction Note: FoxM1-mediated RFC5 expression promotes temozolomide resistance
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The effect of extracellular polymeric substances on MICP solidifying rare earth slags and stabilizing Th and U
Microbially induced carbonate precipitation (MICP) has been used to cure rare earth slags (RES) containing radionuclides (e.g. Th and U) and heavy metals with favorable results. However, the role of microbial ...
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RBM15 Knockdown Impairs the Malignancy of Cervical Cancer by Mediating m6A Modification of Decorin
Cervical cancer (CC) is considered to be the most prevalent female malignancies across the globe and a prime cause of mortality among women. RNA-binding motif protein 15 (RBM15) has been elucidated to particip...
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Open AccessScreens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
Effective therapeutics is much needed for amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease mainly affecting motor neurons. By screening chemical compounds in human patient-derived ...
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Development of Certified Reference Materials of Trace Elements in Gold Solution (GBW02797–GBW02800)
Based on ISO 17034 and ISO Guide 35, a new series of matrix reference materials for 23 trace elements in 2 mg/mL gold solutions with five concentration levels (0, 1, 5, 10 and 20) ng/mL were developed, respect...
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A 4.43-Kb deletion of chromosomal segment containing an ovate family protein confers long capsule in sesame (Sesamum indicum L.)
A 4.43-Kb structural variation in the sesame genome results in the deletion of the Siofp1 gene and induces the long capsule length trait.
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Prognostic Effects of Liver Fibrosis and Steatosis Determined Using Transient Elastography in Patients with Chronic Hepatitis B or C
The prognostic effects of liver fibrosis and steatosis in patients with chronic hepatitis B or C are unclear. We investigated the prognostic effects of liver fibrosis and steatosis determined through transient...
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Article
CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis
Circular RNAs (circRNAs) are well-known to exert significant roles in regulating the pathological processes, including human carcinogenesis. Currently, less is known about their exact roles in head and neck sq...
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A Circular RNA, hsa_circ_0018180 (circPARD3), Triggers Glycolysis and Promotes Malignancy of Head and Neck Squamous Cell Carcinoma Through the miR-5194/ENO1 Axis
Emerging evidence has demonstrated the pivotal roles of circular RNAs (circRNAs) in the modulation of malignancy and pathological progression among multiple human cancers. Glucose metabolism reprogramming is a...
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Immobilization of d-allulose 3-epimerase into magnetic metal–organic framework nanoparticles for efficient biocatalysis
d-allulose is a rare low-calorie sugar that has many fundamental biological functions. d-allulose 3-epimerase from Agrobacterium tumefaciens (AT-DAEase) catalyzes the conversion of d-fructose to d-allulose. The e...
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The crystal structure of a new Co(II) compound and its therapeutic effect of on heart failure
A novel Co(II) compound, that is, [Co4(L)2(H2O)5(DMF)]n·3n(H2O)·n(DMF) (1 H4L = 2,4-bis(4-carboxyphenylamino)-6-bis(carboxymethyl)amino-1,3,5-triazine), has been prepared under solvothermal conditions. Magnetic p...
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The Dynamic Change of Gene-Regulated Networks in Cashmere Goat Skin with Seasonal Variation
The Cashmere goat (Capra hircus) is renowned for its high-quality fiber production trait. The hair cycle in Cashmere goat has an annual rhythm. To deepen the understanding of the molecular foundation of annual rh...
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Open AccessInduction of apoptosis and autosis in cardiomyocytes by the combination of homocysteine and copper via NOX-mediated p62 expression
High levels of homocysteine (Hcy) associated with cardiovascular events are accompanied by increased copper (Cu) concentrations in the blood. Hcy has been shown to promote endothelial dysfunction, whereas the ...
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Open AccessARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway
Advanced breast cancer (BC), especially basal like triple-negative BC (TNBC), is a highly malignant tumor without viable treatment option, highlighting the urgent need to seek novel therapeutic targets. Arylsu...
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Time-resolved Fluorescence Immunoassay (TRFIA) for the Simultaneous Detection of MMP-9 and Lp-PLA2 in Serum
Currently, atherosclerosis accounts for the majority of cardiovascular morbidity and mortality worldwide, and predicting the stability of atherosclerotic plaque is the main method to prevent atherosclerotic de...
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Vitamin D Deficiency Exacerbates Colonic Inflammation Due to Activation of the Local Renin–Angiotensin System in the Colon
The renin–angiotensin system (RAS) is activated in inflammatory bowel disease (IBD), and vitamin D deficiency aggravates the development of colitis, but the relationship between the local colonic RAS and vitam...
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Ziziphus jujuba Mill., a plant used as medicinal food: a review of its phytochemistry, pharmacology, quality control and future research
Jujubae Fructus (ZJF) [called Dazao (大枣) in Chinese], the fruit of Ziziphus jujuba Mill. (ZJ), is utilized as a food and traditional medicine in China. In TCM use, ZJF is traditionally used to treat and nourish t...
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Plant Volatiles Modulate Seasonal Dynamics between Hosts of the Polyphagous Mirid Bug Apolygus lucorum
Plant-derived volatiles play a significant role in host selection of phytophagous insects, but their role in seasonal host shifts remain unclear. The polyphagous mirid bug Apolygus lucorum displays marked seasona...
