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Article
Open AccessTime-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus
Cashmere goat is famous for its high-quality fibers. The growth of cashmere in secondary hair follicles exhibits a seasonal pattern arising from circannual changes in the natural photoperiod. Although several ...
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Article
Open AccessCytological, genetic, and proteomic analysis of a sesame (Sesamum indicum L.) mutant Siyl-1 with yellow–green leaf color
Both photosynthetic pigments and chloroplasts in plant leaf cells play an important role in deciding on the photosynthetic capacity and efficiency in plants. Systematical investigating the regulatory mechanism...
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Article
Open AccessJoint analyses of multi-tissue Hi-C and eQTL data demonstrate close spatial proximity between eQTLs and their target genes
Gene regulation is important for cells and tissues to function. It has been studied from two aspects at the genomic level, the identification of expression quantitative trait loci (eQTLs) and identification of...
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Article
Open AccessEvidence of peripheral olfactory impairment in the domestic silkworms: insight from the comparative transcriptome and population genetics
The insect olfactory system is a highly specific and sensitive chemical detector, which plays important roles in feeding, mating and finding an appropriate oviposition site. The ecological niche of Bombyx mori ha...
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Article
Identification of vernalization responsive genes in the winter wheat cultivar **g841 by transcriptome sequencing
This study aimed to identify vernalization responsive genes in the winter wheat cultivar **g841 by comparing the transcriptome data with that of a spring wheat cultivar Liaochun10. For each cultivar, seedling...
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Article
Locating a modifier gene of Ovum mutant through crosses between DDK and C57BL/6J inbred strains in mice
A striking infertile phenotype has been discovered in the DDK strain of mouse. The DDK females are usually infertile when crossed with males of other inbred strains, whereas DDK males exhibit normal fertility ...
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Article
Prenatal molecular cytogenetic analysis of a mild dysmorphic fetus with a huge unbalance karyotype involving partial 9p deletion and partial 18q duplication
Partial 9p deletion syndrome and partial 18q duplication syndrome each have distinct clinical features. We describe the prenatal molecular cytogenetic analysis of a de novo unbalanced karyotype with deletion o...
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Article
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
Qiuyin Cai and colleagues report a genome-wide association analysis for breast cancer in 22,780 cases and 24,181 controls from 14 studies as part of the Asia Breast Cancer Consortium. They identify three loci ...
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Article
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk
Wei Zheng and colleagues report the results of a large-scale genome-wide association study of colorectal cancer in East Asians. They identify six new susceptibility loci, including variants near TCF7L2 and TGFB1.
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Article
Open AccessExome sequencing generates high quality data in non-target regions
Exome sequencing using next-generation sequencing technologies is a cost efficient approach to selectively sequencing coding regions of human genome for detection of disease variants. A significant amount of D...
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Article
The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade
Following axonal injury in C. elegans, the growth factor SVH-1 and its cognate receptor tyrosine kinase, SVH-2, act to promote axonal regeneration via activation of the JNK-MAPK pathway.
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Article
Meta-analysis identifies common variants associated with body mass index in east Asians
**ao-Ou Shu and colleagues report a meta-analysis of genome-wide association studies for body mass index (BMI) in east Asians. They identify three new genetic loci associated with BMI.
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Article
Cervid satellite DNA and karyotypic evolution of Indian muntjac
Five satellite DNA families (designated as satellite I–V) have been identified in the Cervidae so far. Among those, satellite I, II and IV are centromere specific. Satellite I and II are shared by large number...
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Article
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia
Hamish Scott and colleagues report that germline mutations in GATA2 segregate with myelodysplastic syndrome and acute myeloid leukemia in four pedigrees. The resulting alterations occur in a conserved zinc finger...
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Article
Erratum: Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Nat. Genet. 42, 332–337 (2010); published online 14 March 2010; corrected after print 29 March 2011 In the version of this article initially published, Kathryn Roeder's affiliation was incorrect. Her correct a...
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Article
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population
Qing Wang and colleagues report a genome-wide association study for coronary artery disease (CAD) in a Chinese Han population. They identify a locus on chromosome 6p24.1 newly associated with CAD.
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Article
Genome-wide association identifies multiple ulcerative colitis susceptibility loci
Mark Seielstad and colleagues report results of a large genome-wide association and replication study of ulcerative colitis. The work identifies several new risk loci for this disease and provides further insi...
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Article
Complex genomic organization of Indian muntjac centromeric DNA
A 69-kb Indian muntjac bacterial artificial chromosome (BAC) clone that screened positive for Cervid satellites I and IV was selected for complete sequence analysis and further characterization. The sequences ...
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Article
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1
Wei Zheng and colleagues carried out a genome-wide association study of breast cancer in Chinese women and discovered risk variants on 6q25.1 located upstream of the gene encoding estrogen receptor 1 (ESR1). They...
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Article
Open AccessThe UDP-glucosyltransferase multigene family in Bombyx mori
Glucosidation plays a major role in the inactivation and excretion of a great variety of both endogenous and exogenous compounds. A class of UDP-glycosyltransferases (UGTs) is involved in this process. Insect ...