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  1. Article

    Open Access

    Nucleotide imbalance decouples cell growth from cell proliferation

    Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes i...

    Frances F. Diehl, Teemu P. Miettinen, Ryan Elbashir in Nature Cell Biology (2022)

  2. No Access

    Article

    AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation

    AID/APOBEC deaminases, which convert cytosine bases to uracils in DNA and RNA, have recently been assigned a role in epigenetic regulation as components of DNA demethylation pathways. A systematic study shows ...

    Christopher S Nabel, Huijue Jia, Yu Ye, Li Shen in Nature Chemical Biology (2012)