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Article

Nucleotide imbalance decouples cell growth from cell proliferation

Nucleotide metabolism supports RNA synthesis and DNA replication to enable cell growth and division. Nucleotide depletion can inhibit cell growth and proliferation, but how cells sense and respond to changes i...

Frances F. Diehl, Teemu P. Miettinen, Ryan Elbashir… in Nature Cell Biology (2022)