10 Result(s)

Article

Identification of post-cardiac arrest blood pressure thresholds associated with outcomes in children: an ICU-Resuscitation study

Though early hypotension after pediatric in-hospital cardiac arrest (IHCA) is associated with inferior outcomes, ideal post-arrest blood pressure (BP) targets have not been established. We aimed to leverage pr...

Monique M. Gardner, David A. Hehir, Ron W. Reeder, Tageldin Ahmed… in Critical Care (2023)

Article

Artificial intelligence-based clinical decision support in pediatrics

Machine learning models may be integrated into clinical decision support (CDS) systems to identify children at risk of specific diagnoses or clinical deterioration to provide evidence-based recommendations. Th...

Sriram Ramgopal, L. Nelson Sanchez-Pinto, Christopher M. Horvat… in Pediatric Research (2023)

Article

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

To study the efficacy of lopinavir-ritonavir and hydroxychloroquine in critically ill patients with coronavirus disease 2019 (COVID-19).

Yaseen M. Arabi, Anthony C. Gordon, Lennie P. G. Derde… in Intensive Care Medicine (2021)

Article

Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept

Intracranial compliance refers to the relationship between a change in intracranial volume and the resultant change in intracranial pressure (ICP). Measurement of compliance is useful in managing cardiovascula...

Michael S. Wolf, Jaskaran Rakkar, Christopher M. Horvat… in Neurocritical Care (2021)

Article

A qualitative research framework for the design of user-centered displays of explanations for machine learning model predictions in healthcare

There is an increasing interest in clinical prediction tools that can achieve high prediction accuracy and provide explanations of the factors leading to increased risk of adverse outcomes. However, approaches...

Amie J. Barda, Christopher M. Horvat… in BMC Medical Informatics and Decision Making (2020)

Article

Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children

The objective of this study was to characterize the population pharmacokinetics of fentanyl and identify factors that contribute to exposure variability in critically ill pediatric patients.

Fanuel T. Hagos, Christopher M. Horvat, Alicia K. Au… in Clinical Pharmacokinetics (2019)

Article

The path to great pediatric septic shock outcomes

Stefanie G. Ames, Christopher M. Horvat, Arno Zaritsky, Joseph A. Carcillo in Critical Care (2018)

Article

ABCB1 genotype is associated with fentanyl requirements in critically ill children

The gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may ...

Christopher M Horvat, Alicia K Au, Yvette P Conley… in Pediatric Research (2017)