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    Article

    Temporal Patterns in Brain Tissue and Systemic Oxygenation Associated with Mortality After Severe Traumatic Brain Injury in Children

    Brain tissue hypoxia is an independent risk factor for unfavorable outcomes in traumatic brain injury (TBI); however, systemic hyperoxemia encountered in the prevention and/or response to brain tissue hypoxia ...

    Jaskaran Rakkar, Justin Azar, Jonathan H. Pelletier, Alicia K. Au… in Neurocritical Care (2023)

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    Cerebral Resuscitation and Traumatic and Hypoxic-Ischemic Brain Injury

    The need for improved cerebral resuscitation was born out of progress – advancements in resuscitation, intensive care, and rehabilitation have decreased mortality associated with brain injury in infants and ch...

    Ericka L. Fink, Alicia K. Au, Dennis Simon, Patrick M. Kochanek… in Pediatric Critical Care (2021)

  3. Article

    Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children

    The objective of this study was to characterize the population pharmacokinetics of fentanyl and identify factors that contribute to exposure variability in critically ill pediatric patients.

    Fanuel T. Hagos, Christopher M. Horvat, Alicia K. Au… in Clinical Pharmacokinetics (2019)

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    Brain-Specific Serum Biomarkers Predict Neurological Morbidity in Diagnostically Diverse Pediatric Intensive Care Unit Patients

    Unexpected neurological morbidity in Pediatric Intensive Care Units (PICUs) remains high and is difficult to detect proactively. Brain-specific biomarkers represent a novel approach for early detection of neur...

    Alicia K. Au, Michael J. Bell, Ericka L. Fink, Rajesh K. Aneja… in Neurocritical Care (2018)

  5. Article

    ABCB1 genotype is associated with fentanyl requirements in critically ill children

    The gene ABCB1 encodes p-glycoprotein, a xenobiotic efflux pump capable of transporting certain opioids, including fentanyl. ABCB1 genotype has been previously associated with patient opioid requirements and may ...

    Christopher M Horvat, Alicia K Au, Yvette P Conley… in Pediatric Research (2017)

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    Article

    Autophagy Biomarkers Beclin 1 and p62 are Increased in Cerebrospinal Fluid after Traumatic Brain Injury

    Autophagy is a process that recycles damaged proteins and organelles. Beclin 1 is involved in the nucleation phase, while p62 is consumed during the elongation phase. We hypothesized that these autophagy bioma...

    Alicia K. Au, Rajesh K. Aneja, Hülya Bayır, Michael J. Bell… in Neurocritical Care (2017)

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    Article

    Development of a Pediatric Neurocritical Care Service

    To describe the development of a Pediatric Neurocritical Care (PNCCM) service; define the patient population that requires the service and describe important outcome parameters.

    Michael J. Bell, Jessica Carpenter, Alicia K. Au, Robert F. Keating… in Neurocritical Care (2009)