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  1. Article

    Author Correction: Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

    J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen… in Nature (2022)

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    Article

    PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

    Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the immunosuppressive tumor microe...

    Vivek Narayan, Julie S. Barber-Rotenberg, In-Young Jung, Simon F. Lacey… in Nature Medicine (2022)

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    Article

    Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

    The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers1–7. However, little is known about the long-term potential and clonal stabili...

    J. Joseph Melenhorst, Gregory M. Chen, Meng Wang, David L. Porter, Changya Chen… in Nature (2022)

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    Protocol

    iGUIDE Method for CRISPR Off-Target Detection

    With the advent of genome editing technologies, scientists have recognized that these technologies can be prone to nonspecific or off-target activity. As many areas of the genome are sensitive and can give ris...

    Christopher L. Nobles in Computational Methods in Synthetic Biology (2021)

  5. Article

    Open Access

    iGUIDE: an improved pipeline for analyzing CRISPR cleavage specificity

    Genome engineering methods have advanced greatly with the development of programmable nucleases, but methods for quantifying on- and off-target cleavage sites and associated deletions remain nascent. Here, we ...

    Christopher L. Nobles, Shantan Reddy, January Salas-McKee, **aojun Liu… in Genome Biology (2019)

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    Article

    Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    We report a patient relapsing 9 months after CD19-targeted CAR T cell (CTL019) infusion with CD19– leukemia that aberrantly expressed the anti-CD19 CAR. The CAR gene was unintentionally introduced into a single l...

    Marco Ruella, Jun Xu, David M. Barrett, Joseph A. Fraietta… in Nature Medicine (2018)

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    Article

    Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

    Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies1–3. In this strategy, the T cell genome is modified by integration of viral vectors or transpo...

    Joseph A. Fraietta, Christopher L. Nobles, Morgan A. Sammons, Stefan Lundh… in Nature (2018)