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3 Result(s)

within Christopher J. Bohlen Remove this filter English Remove this filter Biomedicine, general Remove this filter

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  1. No Access

    Article

    Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

    μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pain). A com...

    Gregory Corder, Vivianne L Tawfik, Dong Wang, Elizabeth I Sypek… in Nature Medicine (2017)

  2. No Access

    Article

    Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens

    Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remain incompletely unders...

    Michael S. Haney, Christopher J. Bohlen, David W. Morgens… in Nature Genetics (2018)

  3. No Access

    Article

    Integrative in situ map** of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease

    Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However, understanding the spatiotemporal dynamics underlying pathology can...

    Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt… in Nature Neuroscience (2023)