6 Result(s)
within
Christopher J. Bohlen
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Article
Integrative in situ map** of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease
Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However, understanding the spatiotemporal dynamics underlying pathology can...
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Article
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Phagocytosis is required for a broad range of physiological functions, from pathogen defense to tissue homeostasis, but the mechanisms required for phagocytosis of diverse substrates remain incompletely unders...
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Article
Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pain). A com...
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Article
Neurotoxic reactive astrocytes are induced by activated microglia
Reactive astrocytes are strongly induced by central nervous system (CNS) injury and disease, but their role is poorly understood. Here we show that a subtype of reactive astrocytes, which we termed A1, is indu...
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Article
Partial De Novo Sequencing and Unusual CID Fragmentation of a 7 kDa, Disulfide-Bridged Toxin
A 7 kDa toxin isolated from the venom of the Texas coral snake (Micrurus tener tener) was subjected to collision-induced dissociation (CID) and electron-transfer dissociation (ETD) analyses both before and after ...
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Article
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
The bite of the Texas coral snake, although not fatal, causes excruciating and long-lasting pain. The toxin involved has now been characterized. The purified active component (MitTx) results from an unusual co...
