6 Result(s)
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Christopher J Wilkinson
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Article
Open AccessCep70 and Cep131 contribute to ciliogenesis in zebrafish embryos
The centrosome is the cell's microtubule organising centre, an organelle with important roles in cell division, migration and polarity. However, cells can divide and flies can, for a large part of development,...
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Article
Open AccessPolarization and orientation of retinal ganglion cells in vivo
In the absence of external cues, neurons in vitro polarize by using intrinsic mechanisms. For example, cultured hippocampal neurons extend arbitrarily oriented neurites and then one of these, usually the one near...
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Article
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
The molecular basis of nephronophthisis1, the most frequent genetic cause of renal failure in children and young adults, and its association with retinal degeneration and cerebellar vermis aplasia in Joubert synd...
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Article
The Polo kinase Plk4 functions in centriole duplication
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division1,2. By contrast, the functions of other mam...
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Article
Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase
Entry into mitosis occurs after activation of Cdk1, resulting in chromosome condensation in the nucleus and centrosome separation, as well as increased microtubule nucleation activity in the cytoplasm. The act...
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Proteomic characterization of the human centrosome by protein correlation profiling
The centrosome is the major microtubule-organizing centre of animal cells and through its influence on the cytoskeleton is involved in cell shape, polarity and motility. It also has a crucial function in cell ...
