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Article
Open AccessPharmacological treatment of cancer pain and opioid induced nausea and vomiting: online survey and comparison with current guidelines
We assumed that in Palliative Care, even in common clinical situations, the choice of drugs differs substantially between physicians. Therefore, we assessed the practice of pharmaceutical treatment choices of ...
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Article
Open AccessInterrater agreement of multi-professional case review as reference standard for specialist palliative care need: a mixed-methods study
A wide variety of screening tools for the need for specialist palliative care (SPC) have been proposed for the use in oncology. However, as there is no established reference standard for SPC need to compare th...
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Article
Open AccessTranscutaneous electrical nerve stimulation for advanced cancer pain inpatients in specialist palliative care—a blinded, randomized, sham-controlled pilot cross-over trial
Transcutaneous electrical nerve stimulation (TENS) is a treatment option for cancer pain, but the evidence is inconclusive. We aimed to evaluate the efficacy and safety of TENS.
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Article
ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3
Soeren Lienkamp, Carsten Bergmann, Friedhelm Hildebrandt and colleagues show that mutations in ANKS6 cause nephronophthisis, a recessive cystic kidney disease. They further identify ANKS6 as a component of a prot...
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Article
Primary cilia regulate mTORC1 activity and cell size through Lkb1
The mTOR pathway is a well-known regulator of cell size, and deregulation of mTOR has been observed in cilia-related diseases. Cilia modulate cell size by restricting LKB-1-mediated activation of AMPK to the b...
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Article
Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1)
Primary cilia have been shown to play an important role in embryonic development as well as in postnatal life. Dysfunctional cilia are associated with situs inversus, retinal abnormalities, impaired mucociliary c...
