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  1. Article

    Open Access

    Biologic Abatement and Capturing Kids’ Outcomes and Flare Frequency in Juvenile Spondyloarthritis (BACK-OFF JSpA): study protocol for a randomized pragmatic trial

    The effectiveness of biologic therapies, primarily tumor necrosis factor inhibitors (TNFi), for children with spondyloarthritis (SpA) has made inactive disease a realistic patient outcome. However, biologic th...

    Pamela F. Weiss, Cora E. Sears, Timothy G. Brandon, Christopher B. Forrest in Trials (2023)

  2. Article

    Open Access

    Clinical data for paediatric research: the Swiss approach

    Continuous improvement of health and healthcare system is hampered by inefficient processes of generating new evidence, particularly in the case of rare diseases and paediatrics. Currently, most evidence is ge...

    Milenko Rakic, Manon Jaboyedoff, Sara Bachmann, Christoph Berger in BMC Proceedings (2021)

  3. Article

    Open Access

    Develo** a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol

    There is a widely recognized need for more pragmatic trials that evaluate interventions in real-world settings to inform decision-making by patients, providers, and health system leaders. Increasing availabili...

    Monica Taljaard, Charles Weijer, Jeremy M. Grimshaw, Adnan Ali, Jamie C. Brehaut in Trials (2018)