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  1. No Access

    Article

    Spatial profiling of early primate gastrulation in utero

    Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the interface of embryonic an...

    Sophie Bergmann, Christopher A. Penfold, Erin Slatery, Dylan Siriwardena… in Nature (2022)

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    Article

    Sequential enhancer state remodelling defines human germline competence and specification

    Germline–soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGCs and ste...

    Walfred W. C. Tang, Aracely Castillo-Venzor, Wolfram H. Gruhn… in Nature Cell Biology (2022)

  3. Article

    Open Access

    Building a stem cell-based primate uterus

    The uterus is the organ for embryo implantation and fetal development. Most current models of the uterus are centred around capturing its function during later stages of pregnancy to increase the survival in p...

    Sophie Bergmann, Magdalena Schindler, Clara Munger… in Communications Biology (2021)

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    Inferring Gene Regulatory Networks from Multiple Datasets

    Gaussian process dynamical systems (GPDS) represent Bayesian nonparametric approaches to inference of nonlinear dynamical systems, and provide a principled framework for the learning of biological networks fro...

    Christopher A. Penfold, Iulia Gherman, Anastasiya Sybirna… in Gene Regulatory Networks (2019)