20 Result(s)
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Protocol
Map** of Linear B-Cell Epitopes on Viral Polypeptides by Multiple Peptide Synthesis and Fine Tuning Sensitivity and Specificity of the Identified Peptide Antigens for Application in Virus Diagnosis
This chapter focuses on methods for epitope map** on novel viral polypeptrdes and on fine tuning sensitivity and spectficity of the identified peptide antigens for application in virus diagnosis. Because of ...
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Article
Comparative Analysis of Different Puberty Inhibiting Mechanisms of Two GnRH Agonists and the GnRH Antagonist Cetrorelix Using a Female Rat Model
GnRH agonists are the established treatment of precocious puberty caused by premature stimulation of gonadotropin secretion. It has been reported that after an initial stimulation (“flare-up”) they reduce LH s...
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Article
Serum C-reactive protein: a prognostic factor in metastatic urothelial cancer of the bladder
Until today, there is no reliable prognostic or predictive parameter for the prognosis of patients with metastatic urothelial cancer of the bladder prior to chemotherapy. Recently, serum C-reactive protein (CR...
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Chapter
Metastatic Germ Cell Cancer: The Intermediate-Prognosis Risk Category
With the identification of several patient characteristics with prognostic impact on long term survival a scoring system was introduced in 1997 by the International Germ Cell Cancer Collaborative Group (IGCCCG...
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Chapter
Extragonadale Keimzelltumoren
Extragonadale Keimzelltumoren (EGZT) stellen den malignen Transformationsprozess von Keimzellen dar ohne Vorliegen eines gonadalen Fokus. EGZT machen bis zu 5 % der Keimzelltumoren (KZT) aus. EGZT entstehen du...
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Article
Cisplatin-refraktäre Keimzelltumoren
Trotz der im Allgemeinen exzellenten Heilungsaussichten für Keimzelltumorpatienten sind Patienten mit Cisplatin-refraktärer Erkrankung weiterhin mit einer sehr ungünstigen Prognose konfrontiert.
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Article
Retinal toxicity after cisplatin-based chemotherapy in patients with germ cell cancer
Visual impairment represents an infrequent form of cisplatin-induced neurotoxicity; however, visual deterioration has been reported in several studies. To evaluate potential morphological and functional retina...
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Article
Treatment of refractory germ-cell tumours with single-agent cabazitaxel: a German Testicular Cancer Study Group case series
Outcomes of multiply relapsed, refractory germ-cell tumour (GCT) patients remain poor with an overall survival (OS) of a few months only. Thus, new therapeutic advances are urgently needed. Cabazitaxel has sho...
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Living Reference Work Entry In depth
Kindliche Hirntumoren bei Erwachsenen: Ependymale Tumoren
Ependymome haben bei Kindern eine Häufigkeit von 10 % der primären Hirntumoren, bei Erwachsenen sind sie deutlich seltener. Die Klassifikation erfolgt kombiniert histologisch und molekular nach den Richtlinien...
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Article
Thromboembolische Komplikationen und Thromboseprophylaxe bei fortgeschrittenen testikulären Keimzelltumoren
Testikuläre Keimzelltumoren (TGCT) stellen die häufigste Neoplasie des jungen Mannes dar. Die hohen Ansprechraten auf eine cisplatinbasierte Chemotherapie führt bei diesen Tumoren selbst in metastasierten Stad...
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Article
Primär mediastinale Keimzelltumoren – eine interdisziplinäre Herausforderung
Primär mediastinale Keimzelltumoren entstehen im vorderen Mediastinum. Sie sind histologisch mit männlichen Keimzelltumoren des Hodens identisch, weisen aber eine distinkte Biologie und eine schlechtere Progno...
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Article
Open AccessThe prognostic significance of lactate dehydrogenase levels in seminoma patients with advanced disease: an analysis by the Global Germ Cell Tumor Collaborative Group (G3)
The prognostic significance of lactate dehydrogenase (LDH) in patients with metastatic seminoma is not defined. We investigated the prognostic impact of LDH levels prior to first-line systemic treatment and ot...
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Living Reference Work Entry In depth
Extragonadale Keimzelltumoren
Extragonadale Keimzelltumoren (EGZT) stellen den malignen Transformationsprozess von Keimzellen dar ohne Vorliegen eines gonadalen Fokus. EGZT machen bis zu 5 % der Keimzelltumoren (KZT) aus. EGZT entstehen du...
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Article
Open AccessPeritoneal carcinosis in male germ cell tumor patients: a registry study compiled by the German Testicular Cancer Study Group (GTCSG)
To report on the clinical characteristics, outcome, and frequency of peritoneal carcinosis (PC) in patients with advanced germ cell tumors (GCT), a multicenter registry analysis was carried out.
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Article
Open AccessApproaches of stem cell mobilization in a large cohort of metastatic germ cell cancer patients
High-dose chemotherapy (HD-Cx) in refractory germ cell cancer (GCC) is effective but limited data are available concerning the optimal approach for stem cell mobilization (SCM) in these patients. In this analy...
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Article
Multimodale Therapie des Hodentumors: wann Chemotherapie, Operation oder Strahlentherapie?
Um optimale Therapieergebnisse zu erzielen sind metastasierte Hodentumorpatienten auf eine histologie- und stadienadaptierte Therapie angewiesen.
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Chapter
Extragonadale Keimzelltumoren
Extragonadale Keimzelltumoren (EGZT) stellen den malignen Transformationsprozess von Keimzellen dar ohne Vorliegen eines gonadalen Fokus. EGZT machen bis zu 5 % der Keimzelltumoren (KZT) aus. EGZT entstehen du...
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Article
Open AccessMolecular and histopathological characterization of seminoma patients with highly elevated human chorionic gonadotropin levels in the serum
Approximately 30% of seminoma (SEM) patients present with moderately elevated human chorionic gonadotropin (hCG) levels at first diagnosis. In case of high hCG serum levels, the presence of a non-SEM component...
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Article
Open AccessLong-term cardiotoxicity in germ cell cancer survivors after platinum-based chemotherapy: cardiac MR shows impaired systolic function and tissue alterations
Long-term toxicities of germ cell cancer (GCC) treatment are of particular importance in young men with a life expectancy of several decades after curative treatment. This study aimed to investigate the long-t...
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Article
Open AccessMultidisciplinary survey on use of feeding tubes in head and neck cancer patients undergoing chemoradiotherapy in Germany—the SUFEETUBE project
Data on enteral tube feeding in head and neck cancer (HNC) patients undergoing chemoradiotherapy vary considerably between German institutions. This survey aims to investigate the management of feeding tubes i...
