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  1. No Access

    Article

    Mitochondriale Transhydrogenase: Yin und Yang der antioxidativen Kapazität

    Mitochondria are the main source for ATP, but also reactive oxygen species (ROS). While NADH is required for ATP production, NADPH regenerates anti-oxidative capacity to prevent excessive ROS emission. The mit...

    Albrecht Von Hardenberg, Alexander Nickel, Christoph Maack in BIOspektrum (2017)

  2. Article

    Open Access

    Empagliflozin effects on iron metabolism as a possible mechanism for improved clinical outcomes in non-diabetic patients with systolic heart failure

    Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve clinical outcomes in patients with heart failure (HF), but mechanisms of action are incompletely understood. In the EMPA-TROPISM trial, empagliflozin ...

    Christiane E. Angermann, Carlos G. Santos-Gallego… in Nature Cardiovascular Research (2023)

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    Article

    Bile acids for diabetic cardiomyopathy

    Diabetes can cause heart failure by a toxic accumulation of lipids in cardiac myocytes, which impairs their function. This work shows that stimulation of the bile acid receptor TGR5 limits fatty acid uptake in...

    David Weissman, Christoph Maack in Nature Metabolism (2024)