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Open AccessEffective Apixaban removal using hemoadsorption during emergent open-heart surgery: a case report and narrative literature review
The management of hemostasis in patients medicated with apixaban (Eliquis) undergoing emergency cardiac surgery is exceedingly difficult. The body’s natural elimination pathways for apixaban prove ineffective ...
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Open AccessExperiencing Data on Location: A Case Study of Visualizing Air Quality for Citizens
Visualizing urban data has different purposes. Besides more traditional goals such as supporting experts to decide on smart city policies, supporting citizens to understand aspects of the city relevant to one’...
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Open AccessDesign-features of bubble-prone experimental asset markets with a constant FV
Experimental asset markets with a constant fundamental value (\(\mathrm {\textsc {fv}}\)FV) have grown in importance in recent years. A methodological examination of the robustness of experimental results in such...
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Open AccessScale matters: risk perception, return expectations, and investment propensity under different scalings
With a novel experimental design we investigate whether risk perception, return expectations, and investment propensity are influenced by the scale of the vertical axis in charts. We explore this for two prese...
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Publisher Correction: Actively personalized vaccination trial for newly diagnosed glioblastoma
The additional author support information was erroneously omitted from the Supplementary Information. This has been corrected online.
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Open AccessPitfalls in TAMVI: experience with the repositionable Lotus® Valve System
Simultaneous transapical implantation of transcatheter heart valves in the native mitral and aortic position may be considered as an alternative to surgical valve replacement in high-risk patients presenting w...
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Erratum: Mutant MHC class II epitopes drive therapeutic immune responses to cancer
Nature 520, 692–696 (2015); doi:10.1038/nature14426 In this Letter, there were minor formatting errors in the poly‐neo‐epitope RNA in Fig. 3a, which occurred during the production process; this figure has been...
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Open AccessCancer classification using the Immunoscore: a worldwide task force
Prediction of clinical outcome in cancer is usually achieved by histopathological evaluation of tissue samples obtained during surgical resection of the primary tumor. Traditional tumor staging (AJCC/UICC-TNM ...
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Open AccessDefining the critical hurdles in cancer immunotherapy
Scientific discoveries that provide strong evidence of antitumor effects in preclinical models often encounter significant delays before being tested in patients with cancer. While some of these delays have a ...
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Open AccessSelective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2
Colon cancer-associated MS4A12 is a novel colon-specific component of store-operated Ca2+ (SOC) entry sensitizing cells for epidermal growth factor (EGF)-mediated effects on proliferation and chemotaxis. In the p...
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Open Access(±)-Catechin: Chemical Weapon, Antioxidant, or Stress Regulator?
(±)-Catechin is a flavan-3-ol that occurs in the organs of many plant species, especially fruits. Health-beneficial effects have been studied extensively, and notable toxic effects have not been found. In cont...
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Austria: investigation likely to have serious consequences
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64 OXIPATIVELY MODIFIED HUMAN LOW DENSITY LIPOPROTEINS (LDLox ) INDUCE LEUKOCYTE ADHESION TO VASCULAR ENDOTHELIUM OF HAMSTERS IN VIVO. FISH OIL DIET INHIBITS THIS EFFECT
Adhesion of leukocytes to the microvascular endothelium is a common feature in disorders such as ischemia-reperfusion injury and complications of bone marrow transplantation. Using intravital fluorescence micr...
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Abnormal expansions of granular lymphocytes: Reactive lymphocytosis or chronic leukemia? case report and literature review
A case of chronic lymphoproliferative disorder is presented, wherein a morphologically homogeneous population of lymphoid cells displayed properties similar to those described for large granular lymphocytes (L...