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  1. No Access

    Article

    Therapeutic vaccines for cancer: an overview of clinical trials

  2. Development of vaccines for the treatment of cancer has posed many challenges, but results from some recent studies have confirmed the potential for clinical b...

    3. Ignacio Melero, Gustav Gaudernack, Winald Gerritsen… in Nature Reviews Clinical Oncology (2014)

  3. Article

    Open Access

    Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2

    Colon cancer-associated MS4A12 is a novel colon-specific component of store-operated Ca2+ (SOC) entry sensitizing cells for epidermal growth factor (EGF)-mediated effects on proliferation and chemotaxis. In the p...

    Michael Koslowski, Özlem Türeci, Christoph Huber, Ugur Sahin in Molecular Cancer (2009)

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  4. No Access

    Article

    Dissection and molecular analysis of alloreactive CD8+ T cell responses in allogeneic haematopoietic stem cell transplantation

    We applied a cDNA expression screening procedure with cryopreserved non-clonal CD8+ T cell populations (Lennerz et al., Proc. Natl. Acad. Sci. USA 102:16013-8, 2005) to the identification of candidate antigens...

    Catherine Wölfel, Volker Lennerz, Eva Lindemann… in Cancer Immunology, Immunotherapy (2008)

  5. No Access

    Article

    Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA

    Assessment of antigen-specific T-cell responses has been greatly facilitated by development of ELISPOT and intracellular cytokine flow cytometry (CFC) assays. The use of autologous antigen presenting cells tra...

    Sebastian Kreiter, Thorsten Konrad, Martina Sester… in Cancer Immunology, Immunotherapy (2007)

  6. No Access

    Article

    Effect of rituximab on the long-term outcome after high-dose therapy for relapsed B-cell non-Hodgkin’s lymphoma

    To better define the role of rituximab in salvage and high-dose therapy (HDT) for relapsed or refractory non-Hodgkin’s lymphoma (NHL), patients treated before the implementation of rituximab in salvage and HDT (n

    Georg Hess, Thomas Flohr, Karin Kolbe, Sarah Bonn, Martin Schuler… in Annals of Hematology (2006)

  7. No Access

    Article

    A phase I vaccination study with tyrosinase in patients with stage II melanoma using recombinant modified vaccinia virus Ankara (MVA-hTyr)

    A significant percentage of patients with stage II melanomas suffer a relapse after surgery and therefore need the development of adjuvant therapies. In the study reported here, safety and immunological respon...

    Ralf G. Meyer, Cedrik M. Britten, Ulrike Siepmann… in Cancer Immunology, Immunotherapy (2005)

  8. No Access

    Article

    Reduced-intensity conditioning followed by allografting of CD34-selected stem cells and ≤106/kg T cells may have an adverse effect on transplant-related mortality

    In patients undergoing allogeneic peripheral blood stem cell (PBSC) transplantation after reduced-intensity conditioning (RIC), graft-versus-host disease (GVHD) represents a major cause of morbidity and mortal...

    Udo F. Hartwig, Nils Winkelmann, Thomas Wehler, Sebastian Kreiter… in Annals of Hematology (2005)

  9. No Access

    Article

    Subcutaneous injection of interleukin 12 induces systemic inflammatory responses in humans: implications for the use of IL-12 as vaccine adjuvant

    Interleukin 12 (IL-12) is a cytokine with important regulatory functions bridging innate and adaptive immunity. It has been proposed as an immune adjuvant for vaccination therapy of infectious diseases and mal...

    Johanna E. A. Portielje, Wim H. J. Kruit… in Cancer Immunology, Immunotherapy (2005)

  10. No Access

    Article

    Induction of accessory cell function of human alveolar macrophages by inhalation of human natural interleukin-2

     Accessory function allows antigen-presenting cells to produce sufficient secondary signals for optimum T cell proliferation and interleukin-2 (IL-2) production. Alveolar macrophages are inferior accessory cel...

    Gernot Zissel, Walter E. Aulitzky, J. Lorenz… in Cancer Immunology, Immunotherapy (1996)

  11. No Access

    Article

    Acute hematologic effects of interferon alpha, interferon gamma, tumor necrosis factor alpha and Interleukin 2

    This study was designed to investigate acute effects of various doses of the cytokines IFN-alpha, IFN-gamma Interleukin 2 and tumor necrosis factor alpha on white blood cell differential counts. Before initiat...

    Walter E. Aulitzky, Herbert Tilg, Wolfgang Vogel, Wolfgang Aulitzky… in Annals of Hematology (1991)

  12. No Access

    Article

    Morphological and immunological changes of hairy cell leukemia during α-2-interferon therapy

    We describe a patient who presented with the clinical picture of hairy cell leukemia (HCL). Bone marrow and peripheral blood lymphoma cells showed morphological and immunological features of HCL. Under recombi...

    Michael A. Fridrik, Gernot Wahl, Walter Herbinger, Willhelm Schützenberger… in Blut (1989)

  13. No Access

    Article

    The biology of interferon actions

    The interferons comprise a group of proteins which were first identified by their ability to protect cells against virus infections. They are synthesized and secreted by a variety of cell types in response to ...

    Günther Gastl, Christoph Huber in Blut (1988)

  14. Article

    Abnormal expansions of granular lymphocytes: Reactive lymphocytosis or chronic leukemia? case report and literature review

    A case of chronic lymphoproliferative disorder is presented, wherein a morphologically homogeneous population of lymphoid cells displayed properties similar to those described for large granular lymphocytes (L...

    Günther Gastl, Helmut Rumpold, Dietrich Kraft, Claus Gattringer, Gerold Schuler… in Blut (1986)

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  15. No Access

    Article

    Dichteverteilung menschlicher Lymphozyten

    The aim of this study was to analyze the density distribution patterns of subsets of normal human lymphocytes. Density distribution was assessed by equilibrium centrifugation on linear polysucrose — metrizoat ...

    Christoph Huber, Dietger Niederwieser, Günther Gastl, Karin Zier… in Blut (1982)

  16. No Access

    Article

    Dichteverteilung menschlicher Lymphozyten

    The aim of this study was to investigate the prognostic significance of density distribution profiles in non-Hodgkin lymphomas. Density profiles were evaluated by equilibrium centrifugation on linear polysucro...

    Dietger Niederwieser, Christoph Huber, Dieter Lutz, Günther Weiser, Harald Theml… in Blut (1982)