-
Article
Open AccessAntisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer’s disease (AD). The protein expr...
-
Article
Open AccessIndigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice
Bacterial infection is a common finding in patients, who develop medication-related osteonecrosis of the jaw (MRONJ) by the long-term and/or high-dose use of anti-resorptive agents such as bisphosphonate (BPs)...
-
Article
Open AccessThe ERα/KDM6B regulatory axis modulates osteogenic differentiation in human mesenchymal stem cells
Osteoporosis is a highly prevalent public health burden associated with an increased risk of bone fracture, particularly in aging women. Estrogen, an important medicinal component for the preventative and ther...
-
Article
Open AccessGrowth differentiation factor 6, a repressive target of EZH2, promotes the commitment of human embryonic stem cells to mesenchymal stem cells
Mesenchymal stem cells (MSCs) derived from human embryonic stem cells (hESCs) have significant potential for cell-mediated bone regeneration. Our recent study revealed that inhibiting the epigenetic regulator ...
-
Article
Open AccessA study on the morphologic change of palatal alveolar bone shape after intrusion and retraction of maxillary incisors
The purpose of this study is to evaluate the changes in the palatal alveolar bone thickness and find the factors related to the resorption of the palatal alveolar bone caused by tooth movement after the maxill...
-
Article
Open AccessAlveolar bone remodeling during maxillary incisor intrusion and retraction
Maxillary incisor protrusion is a prevalent dental deformity and is often treated by upper incisor intrusion and retraction. The mechanical loading triggers the resorption and apposition of the bone. Alveolar ...
-
Article
Open AccessAuthor Correction: Single CD271 marker isolates mesenchymal stem cells from human dental pulp
In the original version of this Article, Figure 1c was inadvertently assembled with a duplicate of Figure 1b. The correct image for Figure 1c, shown below, has been added in the HTML and PDF versions of the Ar...
-
Article
Open AccessCharacterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers
Mesenchymal stem cell (MSC)-mediated therapy has been shown to be clinically effective in regenerating tissue defects. For improved regenerative therapy, it is critical to isolate homogenous populations of MSC...
-
Article
Open AccessSingle CD271 marker isolates mesenchymal stem cells from human dental pulp
Mesenchymal stem cells (MSCs) are a promising tool in regenerative medicine due to their capacity to differentiate into multiple lineages. In addition to MSCs isolated from bone marrow (BMSCs), adult MSCs are ...
-
Article
Open AccessHistone methyltransferases and demethylases: regulators in balancing osteogenic and adipogenic differentiation of mesenchymal stem cells
Mesenchymal stem cells (MSCs) are characterized by their self-renewing capacity and differentiation potential into multiple tissues. Thus, management of the differentiation capacities of MSCs is important for ...
-
Article
Open AccessKDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells
Mesenchymal stem cells (MSCs) have been identified and isolated from dental tissues, including stem cells from apical papilla, which demonstrated the ability to differentiate into dentin-forming odontoblasts. ...
