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Article
Open AccessSubzero project: comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue
From organs to subcellular organelles, trace element (TE) homeostasis is fundamental for many physiological processes. While often overlooked in early stages, manifested TE disbalance can have severe health co...
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Article
Open AccessExcessive copper impairs intrahepatocyte trafficking and secretion of selenoprotein P
Selenium homeostasis depends on hepatic biosynthesis of selenoprotein P (SELENOP) and SELENOP-mediated transport from the liver to e.g. the brain. In addition, the liver maintains copper homeostasis. Selenium ...
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Article
Open AccessThe MyoPulser field stimulator, a do it yourself programmable electronic pacemaker for contracting cells and tissues
After providing the free software MYOCYTER that analyzes a large amount of data from videos of contracting cells, tissues or organs, we now present an “Arduino”-based programmable, customizable and cost-effective...
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Article
Open AccessNeutrophils incite and macrophages avert electrical storm after myocardial infarction
Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukoc...
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Article
Open AccessThe “MYOCYTER” – Convert cellular and cardiac contractions into numbers with ImageJ
Measurement and quantification of cardiomyocyte or cardiac contractions as important (patho) physiologic parameters require highly specialized and expensive setups of fully integrated hard- and software that m...
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Article
Open AccessAccurate assessment of LV function using the first automated 2D-border detection algorithm for small animals - evaluation and application to models of LV dysfunction
Echocardiography is the most commonly applied technique for non-invasive assessment of cardiac function in small animals. Manual tracing of endocardial borders is time consuming and varies with operator experi...
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Article
Open AccessEvaluation of a commercial multi-dimensional echocardiography technique for ventricular volumetry in small animals
The assessment of ventricular volumes using conventional echocardiography methods is limited with regards to the need of geometrical assumptions. In the present study, we aimed to evaluate a novel commercial s...
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Article
Effect of exercise duration on lactate kinetics after short muscular exercise
Arterial blood lactate concentrations were measured in six normal males before, during and after 3 and 6-min bicycle exercises performed at three different work rates. The lactate recovery curves were fitted t...
