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Open AccessNon-occlusive mesenteric ischemia and intra-arterial vasodilatory therapy in severe shock and multi-organ failure: treating the untreatable?
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Open AccessTargeting the host response in sepsis: current approaches and future evidence
Sepsis, a dysregulated host response to infection characterized by organ failure, is one of the leading causes of death worldwide. Disbalances of the immune response play an important role in its pathophysiolo...
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D-dimer trends in ECMO patients: don’t shoot the messenger
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Open AccessImmunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk
Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying mechanisms is needed to develop targeted therapie...
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Open AccessBridging patients with acute-on-chronic liver failure for transplantation: plasma exchange to stabilize multiorgan failure?
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Open AccessLetter to the Editor: Innovative future concepts of extracorporeal strategies in sepsis and septic shock
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Where is the imperceptible difference?
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Open AccessClinical and biochemical endpoints and predictors of response to plasma exchange in septic shock: results from a randomized controlled trial
Recently, a randomized controlled trial (RCT) demonstrated rapid but individually variable hemodynamic improvement with therapeutic plasma exchange (TPE) in patients with septic shock. Prediction of clinical e...
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It takes two to bleed: anticoagulation intensity and the host’s vascular susceptibility
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Immunomodulation by Tetracyclines in the Critically Ill: An Emerging Treatment Option?
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2022. Other selected articles can be found online at https://www.biomedcentral.com/coll...
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Open AccessUnraveling the secret of re-balancing homeostasis in sepsis: a critical view on extracorporeal blood purification modalities
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Adjuvant therapeutic plasma exchange in septic shock
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Open AccessComparison of anticoagulation strategies for veno-venous ECMO support in acute respiratory failure
Extracorporeal membrane oxygenation (ECMO) support in acute respiratory failure may be lifesaving, but bleeding and thromboembolic complications are common. The optimal anticoagulation strategy balancing these...
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Open AccessDirect acute respiratory distress syndrome after gastric perforation caused by an intragastric balloon: a case report
Acute respiratory distress syndrome (ARDS) is a life-threatening condition and the identification of the underlying direct (pulmonary) or indirect (non-pulmonary) cause is mandatory for a successful treatment....
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Open AccessFirst do no harm—beware the risk of therapeutic plasma exchange in severe COVID-19
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Open AccessEffect of therapeutic plasma exchange on endothelial activation and coagulation-related parameters in septic shock
A dysbalanced coagulation system is part of the pathological host response to infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant activity ultimately lead to microvascul...
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Open AccessInterprofessional two-man team approach for interhospital transport of ARDS-patients under extracorporeal membrane oxygenation: a 10 years retrospective observational cohort study
Extra Corporeal Membrane Oxygenation (ECMO) has become an accepted treatment option for severely ill patients. Due to a limited availability of ECMO support therapy, patients must often be transported to a spe...