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Article
Open AccessCheckpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Programmed death-ligand 1 is a glycoprotein expressed on antigen presenting cells, hepatocytes, and tumors which upon interaction with programmed death-1, results in inhibition of antigen-specific T cell respo...
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Open AccessPublisher Correction: Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessCirculating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients
Chronic hepatitis B (CHB) infection functional cure is defined as sustained loss of HBsAg and several therapeutic strategies are in clinical development designed to pharmacologically reduce serum HBsAg, break ...
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Protocol
Primary Ear Fibroblast Derivation from Mice
Mouse embryonic fibroblasts (MEFs) are commonly utilized as a primary cell culture model and have several advantages over other types of ex vivo-derived cells. However, the successful generation of MEFs is tim...
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Protocol
Short Hairpin RNA (shRNA): Design, Delivery, and Assessment of Gene Knockdown
Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began using this powerful technique to study gene function. This included designing better methods for the succes...
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NLRX1 is a regulator of mitochondrial antiviral immunity
Cytoplasmic RIG-like helicases are sensors of viral RNA, and signal through the mitochondrial adaptor protein MAVS to activate IRF3 and induce type 1 interferon production. This paper shows that a member of th...
