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Article
Small molecules, big targets: drug discovery faces the protein–protein interaction challenge
Protein–protein interactions (PPIs) are increasingly being targeted by drug discovery groups, and there exists great scope for therapeutic modulation of this t...
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Article
High-throughput crystallography for lead discovery in drug design
Knowledge of the three-dimensional structures of target proteins provides a starting point for structure-based approaches to drug design by defining the topogr...
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Article
Direct and sensitive detection of a human virus by rupture event scanning
We have developed a sensitive, economical method that directly detects viruses by making use of the interaction between type 1 herpes simplex virus (HSV1) and specific antibodies covalently attached to the osc...