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Article
Open AccessAlternative splicing in prostate cancer progression and therapeutic resistance
Prostate cancer (CaP) remains the second leading cause of cancer deaths in western men. CaP mortality results from diverse molecular mechanisms that mediate resistance to the standard of care treatments for me...
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Article
Multidrug efflux transporter ABCG2: expression and regulation
The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have expanded the understanding o...
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Article
“Employers” in a Migrant Intensive Industry: Organised Construction in Thane, Maharashtra
As per Census of India 2011, the Mumbai urban agglomeration forms a major urban magnet for migrant construction workers. The construction sector comprises principally informal workers whose conditions of work ...
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Article
Open AccessDownregulation of peripheral PTGS2/COX-2 in response to valproate treatment in patients with epilepsy
Antiepileptic drug therapy has significant inter-patient variability in response towards it. The current study aims to understand this variability at the molecular level using microarray-based analysis of peri...
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Article
Open AccessCyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Epilepsy, a common multifactorial neurological disease, affects about 69 million people worldwide constituting nearly 1% of the world population. Despite decades of extensive research on understanding its unde...
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Article
Open AccessA systematic review and integrative approach to decode the common molecular link between levodopa response and Parkinson’s disease
PD is a progressive neurodegenerative disorder commonly treated by levodopa. The findings from genetic studies on adverse effects (ADRs) and levodopa efficacy are mostly inconclusive. Here, we aim to identify ...
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Article
Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach
Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to ...
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Article
Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory and other cognitive functions. AD can be classified into familial AD (FAD) and sporadic AD (SAD) based on he...
