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  1. Article

    Open Access

    Heat-related illness and dementia: a study integrating epidemiological and experimental evidence

    Heat-related illness (HRI) is commonly considered an acute condition, and its potential long-term consequences are not well understood. We conducted a population-based cohort study and an animal experiment to ...

    Wan-Yin Kuo, Chien-Cheng Huang, Chi-An Chen, Chung-Han Ho in Alzheimer's Research & Therapy (2024)

  2. No Access

    Article

    The impact of photobiomodulation on sleep and life quality in hemodialysis patients: A randomized controlled trial

    The quality of life (QoL) and sleep quality are closely linked to the physical and psychological health of end-stage renal disease (ESRD) patients, especially those underwent hemodialysis (HD) therapy. This st...

    Yi-** Chang, Chih-Ching Lin, Jih-Huah Wu, Ya-Hui Hsieh in Lasers in Medical Science (2024)

  3. No Access

    Article

    Exploring the link between metformin use and adhesive capsulitis of the shoulder: a retrospective cohort study in Taiwan

    The risk of adhesive capsulitis of shoulder in diabetic patients taking metformin has not been evaluated. We aimed for evaluating the relative risk of adhesive capsulitis of shoulder in diabetic patients takin...

    Bing-Sian Lin, Wu-Chien Chien, Chieh-Hua Lu in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

  4. No Access

    Article

    Early Therapeutic Drug Monitoring Optimizes Teicoplanin Use in Febrile Neutropenic Patients with Hematological Malignancies

    A target trough concentration (Cmin) of teicoplanin ≥ 15–20 mg/L between the fourth and sixth day has been suggested for severe infections or management of febrile neutropenia (FN). Owing to no reports discussing...

    Yu-Wen Wang, Hsin-An Hou, Chien-Chin Lin, Hsing-Yu Lin, Pin-Zi Chen in Advances in Therapy (2024)

  5. No Access

    Article

    Efficiency of PGK1 proteins delivered to the brain via a liposomal system through intranasal route administration for the treatment of spinocerebellar ataxia type 3

    A patient-friendly and efficient treatment method for patients with spinocerebellar ataxia type 3 (SCA3) was provided through a nose-to-brain liposomal system. Initially, PGK1 was overexpressed in HEK 293-84Q-...

    Yu-Shuan Chen, Zhen-**ang Hong, Yi-Tung Lin in Drug Delivery and Translational Research (2024)

  6. Article

    Open Access

    Develo** an entrustable professional activity for providing health education and consultation in occupational therapy and examining its validity

    Entrustable Professional Activities (EPA)-based assessment is easily and intuitively used in evaluating the learning outcomes of competency-based medical education (CBME). This study aimed to develop an EPA fo...

    Chung-Pei Fu, Ching-Kai Huang, Yi-Chiun Yang, Wei-Sheng Liao in BMC Medical Education (2024)

  7. Article

    Open Access

    PIKfyve, expressed by CD11c-positive cells, controls tumor immunity

    Cancer treatment continues to shift from utilizing traditional therapies to targeted ones, such as protein kinase inhibitors and immunotherapy. Mobilizing dendritic cells (DC) and other myeloid cells with anti...

    Jae Eun Choi, Yuanyuan Qiao, Ilona Kryczek, Jiali Yu in Nature Communications (2024)

  8. Article

    Open Access

    Improved prediction of anti-angiogenic peptides based on machine learning models and comprehensive features from peptide sequences

    Angiogenesis is a key process for the proliferation and metastatic spread of cancer cells. Anti-angiogenic peptides (AAPs), with the capability of inhibiting angiogenesis, are promising candidates in cancer tr...

    Yun-Chen Lee, Jen-Chieh Yu, Kuan Ni, Yu-Chuan Lin, Ching-Tai Chen in Scientific Reports (2024)

  9. No Access

    Article

    Strategic legislation for the promotion of university–industry collaborations: a case study of Taiwan

    The strategic utilization of technology to enhance industrial competitiveness and product quality is pivotal for economic growth. As universities own more inventions, collaborative efforts between industry and...

    Thanh Hue Truong, Bou-Wen Lin, Ching-Pin Tung in The Journal of Technology Transfer (2024)

  10. Article

    Open Access

    Modeling First-Line Daratumumab Use for Newly Diagnosed, Transplant-Ineligible, Multiple Myeloma: A Cost-Effectiveness and Risk Analysis for Healthcare Payers

    This study aimed to assess the cost-effectiveness of two regimens regarded as the standard of care for the treatment of newly diagnosed, transplant-ineligible multiple myeloma in Singapore: (1) daratumumab, le...

    Diana Beatriz Bayani, Yihao Clement Lin, Chandramouli Nagarajan in PharmacoEconomics - Open (2024)

  11. Article

    Open Access

    Use of phase plate cryo-EM reveals conformation diversity of therapeutic IgG with 50 kDa Fab fragment resolved below 6 Å

    While cryogenic electron microscopy (cryo-EM) is fruitfully used for harvesting high-resolution structures of sizable macromolecules, its application to small or flexible proteins composed of small domains lik...

    Hsin-Hung Lin, Chun-Hsiung Wang, Shih-Hsin Huang, Sung-Yao Lin in Scientific Reports (2024)

  12. No Access

    Article

    Can weekend catch-up sleep decrease the risk of cognitive dysfunction in older adults?

    This study investigated whether weekend catch-up sleep was related to a decreased risk of cognitive dysfunction in older Taiwanese adults by using self-reported diaries and objective accelerometer measurements.

    Chi Hsiao, Wan-Chi Huang, Ming-Chun Hsueh, Chih-Ching Chang in Sleep and Breathing (2024)

  13. Article

    Open Access

    Hypotension prediction index for prevention of intraoperative hypotension in patients undergoing general anesthesia: a randomized controlled trial

    Intraoperative hypotension is a common side effect of general anesthesia. Here we examined whether the Hypotension Prediction Index (HPI), a novel warning system, reduces the severity and duration of intraoper...

    Chih-Jun Lai, Ya-Jung Cheng, Yin-Yi Han, Po-Ni Hsiao, Pei-Lin Lin in Perioperative Medicine (2024)

  14. Article

    Open Access

    High prevalence of exon-13 variants in USH2A-related retinal dystrophies in Taiwanese population

    Biallelic pathogenic variants in USH2A lead to Usher syndrome or non-syndromic retinitis pigmentosa, and shown to have geographical and ethnical distribution in previous studies. This study provided a deeper unde...

    Yu-Wei Lin, Yu-Shu Huang, Chien-Yu Lin, Chao-Wen Lin in Orphanet Journal of Rare Diseases (2024)

  15. Article

    Open Access

    Study on different isolation technology on the performance of blue micro-LEDs array applications

    In this study, a 3 × 3 blue micro-LED array with a pixel size of 10 × 10 μm2 and a pitch of 15 μm was fabricated on an epilayer grown on a sapphire substrate using metalorganic chemical vapor deposition technolog...

    Shao-Hua Lin, Yu-Yun Lo, Yu-Hsuan Hsu, Chien-Chung Lin, Hsiao-Wen Zan in Discover Nano (2024)

  16. No Access

    Article

    Building Institutional Research Workforce in Postsecondary Education: Exploring Institutional Research Professionals’ Conceptualizations of their Professional Identities

    To provide insights into how institutions can scaffold institutional researchers’ construction of strong professional identities, we employed a qualitative approach, rooted in the constructivist paradigm, whic...

    Nothando Sithulile Nkambule, Ching-Hui Lin, I-Hui Lin in Higher Education Policy (2024)

  17. Article

    Open Access

    Emission characterizations and environmental impacts of off-road vehicles

    This study measured particulate matter (PM) and gaseous pollutants in the exhaust of off-road vehicles (excavators, bulldozers) during idling and working. The fingerprint of metals in PM and the emission facto...

    Hsing-Wang Li, Chia-Hsiang Lai, Ku-Fan Chen in Sustainable Environment Research (2024)

  18. No Access

    Article

    Stereo digital image correlation (3D-DIC) for non-contact measurement and refinement of delta robot arm displacement and jerk

    This study proposes using the stereo digital image correlation (3D-DIC) method to measure the delta robot arm displacement and jerk to verify the robot arm end-effector position and improve the absolute accura...

    Shih-Hao Lin, En-Tze Chen, Jia-Jun **ao in The International Journal of Advanced Manu… (2024)

  19. No Access

    Article

    Integrating online partial pair programming and socially shared metacognitive regulation for the improvement of students’ learning

    Many universities around the world were forced to lock down and students had to continue their learning in online environments in response to the COVID-19 pandemic. Teachers thus had to adopt effective and app...

    Chia-Wen Tsai, Michael Yu-Ching Lin in Universal Access in the Information Society (2024)

  20. No Access

    Article

    Industry perspective on power electronics for electric vehicles

    Driven by the global effort towards reduction of carbon dioxide emissions from cars, the gradual phase out of fuel cars accompanied by the rise of electric vehicles (EVs) has become a megatrend. Despite the ra...

    Chang-Ching Tu, Chia-Lung Hung, Kuo-Bin Hong in Nature Reviews Electrical Engineering (2024)

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