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Open AccessAnti-inflammatory reprogramming of microglia cells by metabolic modulators to counteract neurodegeneration; a new role for Ranolazine
Microglia chronic activation is a hallmark of several neurodegenerative diseases, including the retinal ones, possibly contributing to their etiopathogenesis. However, some microglia sub-populations have anti-...
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Article
Open AccessSynaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine
Migraine affects a significant fraction of the world population, yet its etiology is not completely understood. In vitro results highlighted thalamocortical and intra-cortical glutamatergic synaptic gain-of-fu...
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Article
Is it time to revise linezolid dose in elderly patients?
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Open AccessCorrection: Corrigendum: The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa
Scientific Reports 6: Article number: 35919; published online: 24 October 2016; updated: 09 December 2016
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Open AccessThe bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa
Retinitis pigmentosa (RP) comprises a group of inherited pathologies characterized by progressive photoreceptor degeneration. In rodent models of RP, expression of defective genes and retinal degeneration usua...
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Article
Early depolarizing GABA controls critical-period plasticity in the rat visual cortex
The inhibitory neurotransmitter GABA can lead to neuronal depolarization during early brain development caused by a shift in intracellular chloride concentration. Here Deidda et al. show that a brief alteration i...
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Article
Open AccessThe bacterial protein toxin, cytotoxic necrotizing factor 1 (CNF1) provides long-term survival in a murine glioma model
Glioblastomas are largely unresponsive to all available treatments and there is therefore an urgent need for novel therapeutics. Here we have probed the antineoplastic effects of a bacterial protein toxin, the...
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Correction: Corrigendum: AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the develo** cortex
Nat. Neurosci. 12, 1229–1237 (2009); published online 13 September 2009; corrected after print 25 September 2009 In the version of this article initially published, one of the corresponding authors' email addr...
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Article
AP2γ regulates basal progenitor fate in a region- and layer-specific manner in the develo** cortex
The thickness of cortical layers varies among cortical areas. This study reports that the transcription factor AP2γ is specifically required for the generation of layer II/III neurons in the caudal primary vis...
