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Article
Open AccessThe iBuddy experience: A digital simulation-based approach to enhance secondary school students’ privacy awareness
Privacy is a central issue in the digitalization of society and directly concerns all Internet users. Privacy education is part of the picture of a more just digital society: it aims at making users more aware...
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Article
Open AccessAmyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism
Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous studies demonstrate that inflammatory astrocy...
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Article
Open AccessIntracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ing...
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Article
Open AccessTraumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy
Traumatic brain injury (TBI) presents a widespread health problem in the elderly population. In addition to the acute injury, epidemiological studies have observed an increased probability and earlier onset of...
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Article
Open AccessExtracellular vesicles from amyloid-β exposed cell cultures induce severe dysfunction in cortical neurons
Alzheimer’s disease (AD) is characterized by a substantial loss of neurons and synapses throughout the brain. The exact mechanism behind the neurodegeneration is still unclear, but recent data suggests that sp...
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Article
Open AccessProlonged extracorporeal membrane oxygenation therapy for severe acute respiratory distress syndrome in a child affected by rituximab-resistant autoimmune hemolytic anemia: a case report
Autoimmune hemolytic anemia in children younger than 2 years of age is usually characterized by a severe course, with a mortality rate of approximately 10%. The prolonged immunosuppression following specific t...
