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  1. No Access

    Article

    Combining MRI and cognitive evaluation to classify concussion in university athletes

    Current methods of concussion assessment lack the objectivity and reliability to detect neurological injury. This multi-site study uses combinations of neuroimaging (diffusion tensor imaging and resting state ...

    Monica T. Ly, Samantha E. Scarneo-Miller, Adam S. Lepley… in Brain Imaging and Behavior (2022)

  2. Article

    Open Access

    Hesperetin-5,7,3’-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice

    We recently reported that hesperetin-5,7,3’-O-triacetate (HTA) dually inhibited phosphodiesterase (PDE)3/4 with a therapeutic ratio of 20.8. The application and development of PDE4 inhibitors for treating asthma ...

    You-Lan Yang, Chi-Li Chen, Chi-Ming Chen, Wun-Chang Ko in BMC Pharmacology and Toxicology (2017)

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  3. Article

    Open Access

    Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio

    Hesperetin was reported to selectively inhibit phosphodiesterase 4 (PDE4). While hesperetin-7,3'-O-dimethylether (HDME) is a synthetic liposoluble hesperetin. Therefore, we were interested in investigating its se...

    You-Lan Yang, Hsin-Te Hsu, Kuo-Hsien Wang, Cheng-Ying Han… in Journal of Biomedical Science (2011)

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