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Article
Public Perception and Willingness to Pay for Urban Wetland Ecosystem Services: Evidence from China
Due to accelerated urbanization and the lack of positive perception of wetland ecosystem services, urban wetland ecosystems have been severely altered in China. It is crucial to understand public perception an...
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Article
Open AccessCombination of mesenchymal stromal cells and machine perfusion is a novel strategy for organ preservation in solid organ transplantation
Organ preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount of expanded criteria donor (ECD) organs are used clinically...
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Article
Open AccessInduction therapy with mesenchymal stromal cells in kidney transplantation: a meta-analysis
The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety...
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Article
Genetic modification by overexpression of target gene in mesenchymal stromal cell for treating liver diseases
Different hepatoxic factors cause irreversible liver injury, leading to liver failure, cirrhosis, and cancer in mammals. Liver transplantation is the only effective strategy, which can improve the prognosis of...
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Cell Transplantation Therapy for Liver Failure
Liver dysfunction and failure can have diverse etiologies and finally result in irreversible liver failure which is life-threatening all over the world. Although liver transplantation (LT) becomes the optimal ...
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Article
Open AccessSerum ammonia is a strong prognostic factor for patients with acute-on-chronic liver failure
Ammonia is thought to be central to the pathogenesis of hepatic encephalopathy (HE), but its prognostic role in acute-on-chronic liver failure (ACLF) is still unknown. We aimed to determine the association bet...
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Article
Open AccessMesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from liver cirrhosis, liver failure,...
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Article
Open AccessPreconditioning is an effective strategy for improving the efficiency of mesenchymal stem cells in kidney transplantation
The inevitable side effects caused by lifelong immunosuppressive agents in kidney transplantation patients spurred the exploration of novel immunosuppressive strategies with definite curative effects and minim...
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Article
Open AccessTransplantation of mesenchymal stem cells and their derivatives effectively promotes liver regeneration to attenuate acetaminophen-induced liver injury
Acetaminophen (APAP)-induced injury is a common clinical phenomenon that not only occurs in a dose-dependent manner but also occurs in some idiosyncratic individuals in a dose-independent manner. APAP overdose...
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Article
Open AccessThe immunoregulation of mesenchymal stem cells plays a critical role in improving the prognosis of liver transplantation
The liver is supplied by a dual blood supply, including the portal venous system and the hepatic arterial system; thus, the liver organ is exposed to multiple gut microbial products, metabolic products, and to...
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Article
Open AccessThe application of resveratrol to mesenchymal stromal cell-based regenerative medicine
Currently, the transplantation of mesenchymal stromal cells (MSCs) has emerged as an effective strategy to protect against tissue and organ injury. MSC transplantation also serves as a promising therapy for re...
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Article
Improvement of mesenchymal stromal cells and their derivatives for treating acute liver failure
After the death of large numbers of cells in liver tissue is triggered by various hepatotoxic factors, intimidating and life-threatening acute liver failure (ALF) can develop with high mortality and expensive ...
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Article
Open AccessCurrent understanding of adipose-derived mesenchymal stem cell-based therapies in liver diseases
The liver, the largest organ with multiple synthetic and secretory functions in mammals, consists of hepatocytes, cholangiocytes, hepatic stellate cells (HSCs), sinusoidal endothelial cells, Kupffer cells (KCs...
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Article
Open AccessMesenchymal stem cell therapy targeting mitochondrial dysfunction in acute kidney injury
Mitochondria take part in a network of cellular processes that regulate cell homeostasis. Defects in mitochondrial function are key pathophysiological changes during acute kidney injury (AKI). Mesenchymal stem...
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Article
Open AccessGenetic communication by extracellular vesicles is an important mechanism underlying stem cell-based therapy-mediated protection against acute kidney injury
Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells...
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Article
Open AccessModulating autophagy in mesenchymal stem cells effectively protects against hypoxia- or ischemia-induced injury
In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerat...
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Article
Open AccessMelatonin plays critical role in mesenchymal stem cell-based regenerative medicine in vitro and in vivo
Although stem cells have emerged as promising sources for regenerative medicine, there are many potential safety hazards for their clinical application, including tumorigenicity, an availability shortage, sene...
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Article
Open AccessNovel preconditioning strategies for enhancing the migratory ability of mesenchymal stem cells in acute kidney injury
Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (...
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Article
Open AccessAdministration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats
Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lacto...
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Article
Open AccessNoninvasive in-vivo tracing and imaging of transplanted stem cells for liver regeneration
Terminal liver disease is a major cause of death globally. The only ultimate therapeutic approach is orthotopic liver transplant. Because of the innate defects of organ transplantation, stem cell-based therapy...
