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  1. Article

    Open Access

    Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma

    Abnormal lipid metabolism is one of the most prominent metabolic changes in cancer. Studies have shown that lipid metabolism also plays an important role in neuroblastoma. We recently discovered that the insul...

    Haibo Cao, Ran Zhuo, Zimu Zhang, Jianwei Wang, Yanfang Tao… in Cell & Bioscience (2022)

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    Article

    MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway–mediated autophagy

    Autophagy plays an important role in maintaining cell function. Abnormal autophagy leads to cell dysfunction and is associated with many diseases such as tumors, immunodeficiency diseases, lysosomal storage di...

    Zhouteng Tao, Chenxi Feng, Chenmei Mao, ** Ren, Yusi Tai… in Cell Stress and Chaperones (2019)

  3. No Access

    Article

    Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway

    Bis(propyl)-cognitin (B3C), derived from tacrine linked with three methylene (–CH2–) groups, is a dimerized molecule interacting multiple targets. During the past several years, it has been reported as a promi...

    Liting Jiang, Meng Huang, Shujun Xu, Yu Wang, Pengyuan An… in Molecular Neurobiology (2016)