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Article
Open AccessA midbrain GABAergic circuit constrains wakefulness in a mouse model of stress
Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wak...
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Article
BTK Expression Level Prediction and the High-Grade Glioma Prognosis Using Radiomic Machine Learning Models
We aimed to study whether the Bruton’s tyrosine kinase (BTK) expression is correlated with the prognosis of patients with high-grade gliomas (HGGs) and predict its expression level prior to surgery, by constru...
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Chapter and Conference Paper
Research on the Mechanism and Prevention Technology of Casing Deformation Fracturing of Shale Oil
In order to effectively utilize GuLong shale oil, it requires large-scale fracturing. However, the problems caused by casing deformation, such as section loss, severely restrict the efficiency and effectivenes...
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Article
Sleep Disturbance: An Early Sign of Alzheimer’s Disease
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Article
Open AccessHypothalamus-pituitary-adrenal axis involves in anti-viral ability through regulation of immune response in piglets infected by highly pathogenic porcine reproductive and respiratory syndrome virus
The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has been responsible for several viral attacks in the Asian porcine industry, since the first outbreak in China in 2006. Dur...
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Article
Open AccessComparative analysis of apoptotic changes in peripheral immune organs and lungs following experimental infection of piglets with highly pathogenic and classical porcine reproductive and respiratory syndrome virus
Our previous studies have demonstrated that piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) may develop significant thymus atrophy, which related to thymo...
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Article
High-level expression and immunogenicity of a porcine circovirus type 2 capsid protein through codon optimization in Pichia pastoris
The porcine circovirus type 2 (PCV2) capsid protein (Cap) is an important antigen for the development of vaccines. To achieve high-level expression of recombinant PCV2 Cap in Pichia pastoris, the wild-type Cap (w...
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Article
Open AccessElectric field-induced oscillation of sessile droplets
We report a novel oscillatory behavior of a sessile droplet on a hydrophobic surface. The droplet was placed on an electrode with a hydrophobic surface and close to, but not touching, a second needle-like elec...
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Article
Unique evolution characteristics of the envelope protein of EIAVLN40, a virulent strain of equine infectious anemia virus
The Chinese equine infectious anemia virus (EIAV) virulent strain EIAVLN40 is derived from a naturally occurring virus by continuously passing in horses for 16 generations. Its genome sequence is 23% different fr...
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Article
Genomic comparison between attenuated Chinese equine infectious anemia virus vaccine strains and their parental virulent strains
A lentiviral vaccine, live attenuated equine infectious anemia virus (EIAV) vaccine, was developed in the 1970s, and this has made tremendous contributions to the control of equine infectious anemia (EIA) in C...
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Article
Genomic analysis of an effective lentiviral vaccine-attenuated equine infectious anemia virus vaccine EIAVFDDV13
Chinese equine infectious anemia virus (EIAV) attenuated vaccine is the first lentiviral vaccine with a successful application. In order to understand the correlation of viral genomic mutations with viral atte...
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Article
In vivo evolution of the gp90 gene and consistently low plasma viral load during transient immune suppression demonstrate the safety of an attenuated equine infectious anemia virus (EIAV) vaccine
To study the in vivo evolution of the attenuated Chinese equine infectious anemia virus (EIAV) vaccine, viral gp90 gene variation and virus replication in immunosuppressed hosts were investigated. The results sho...
