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Article
Open AccessTBX15/miR-152/KIF2C pathway regulates breast cancer doxorubicin resistance via promoting PKM2 ubiquitination
Chemoresistance is a critical risk problem for breast cancer treatment. However, mechanisms by which chemoresistance arises remains to be elucidated. The expression of T-box transcription factor 15 (TBX-15) wa...
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Protocol
In Vivo Functional Analysis of Nonconserved Human lncRNAs Using a Humanized Mouse Model
LncRNAs (long noncoding RNAs) are transcripts that are at least 200 nucleotides long and lack any predicted coding potential. Whereas significant progress has been made in deciphering the function of mouse lnc...
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Article
Open AccessIn vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits
Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved. Although lncRNAs have been shown to function in diverse pathophysiological processes in mice, it ...
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Article
Open AccessEstrogen-induced miR-196a elevation promotes tumor growth and metastasis via targeting SPRED1 in breast cancer
Estrogen plays a critical role in breast cancer (BC) progression through estrogen receptor (ER)-mediated gene regulation. Emerging studies suggest that the malignant progress of BC cells is influenced by the c...
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Article
Open AccessDeficiency of Mkrn2 causes abnormal spermiogenesis and spermiation, and impairs male fertility
Although recent studies have shed insights on some of the potential causes of male infertility, new underlining molecular mechanisms still remain to be elucidated. Makorin-2 (Mkrn2) is an evolutionarily conserved...
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Article
Determination of amino acids in Panax notoginseng by microwave hydrolysis and derivatization coupled with capillary zone electrophoresis detection
The microwave hydrolysis and derivatization coupled with capillary electrophoresis detection were developed for the separation and determination of the amino acids in Panax notoginseng. The experimental condition...
